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1. (WO2017136435) COMPOUNDS FOR MODULATING FC-EPSILON-RI-BETA EXPRESSION AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136435 International Application No.: PCT/US2017/016042
Publication Date: 10.08.2017 International Filing Date: 01.02.2017
IPC:
C12N 15/11 (2006.01) ,A61K 31/7088 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
Applicants:
THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTE OF HEALTH [US/US]; 6011 Executive Blvd., Suite 325 MSC 7660 Bethesda, MD 20892-7660, US
Inventors:
CRUSE, Glenn, P.; US
METCALFE, Dean, D.; US
Agent:
TRAVER, Robert, D.; US
Priority Data:
62/289,44701.02.2016US
Title (EN) COMPOUNDS FOR MODULATING FC-EPSILON-RI-BETA EXPRESSION AND USES THEREOF
(FR) COMPOSÉS PERMETTANT DE MODULER L'EXPRESSION DE FC-EPSILON-RI-BÊTA ET UTILISATIONS CORRESPONDANTES
Abstract:
(EN) Methods for treating diseases and conditions mediated by the high affinity IgE receptor (FcεRI). Antisense oligomers for modulating splicing of mRNA encoding the FcεRIβ protein, thereby down-regulating cell-surface expression of FcεRI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation.
(FR) La présente invention concerne des procédés permettant de traiter des maladies et des états pathologiques induits par le récepteur IgE à haute affinité (FcεRI). L'invention concerne également des oligomères antisens permettant de moduler l'épissage d'ARNm codant la protéine FcεRIβ, régulant ainsi négativement l'expression à la surface cellulaire de FcεRI, ainsi que des utilisations des oligomères antisens pour inhiber une dégranulation, une libération de cytokines, une migration et une prolifération des mastocytes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)