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1. (WO2017135273) PEPTIDE HAVING CELL MEMBRANE PERMEABILITY, CONSTRUCT, AND METHOD FOR TRANSPORTING CARGO MOLECULE INTO CELL
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/135273 International Application No.: PCT/JP2017/003520
Publication Date: 10.08.2017 International Filing Date: 01.02.2017
IPC:
C07K 7/00 (2006.01) ,C07K 19/00 (2006.01) ,C12N 15/09 (2006.01) ,A61K 45/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
Applicants:
公益財団法人ヒューマンサイエンス振興財団 JAPAN HEALTH SCIENCES FOUNDATION [JP/JP]; 東京都千代田区岩本町二丁目11番1号 11-1, Iwamoto-cho 2-chome, Chiyoda-ku, Tokyo 1010032, JP
Inventors:
出水 庸介 DEMIZU Yosuke; JP
栗原 正明 KURIHARA Masaaki; JP
三澤 隆史 MISAWA Takashi; JP
Agent:
特許業務法人前田特許事務所 MAEDA & PARTNERS; 大阪府大阪市北区堂島浜1丁目2番1号 新ダイビル23階 Shin-Daibiru Bldg. 23F, 2-1, Dojimahama 1-chome, Kita-ku, Osaka-shi, Osaka 5300004, JP
Priority Data:
2016-01841602.02.2016JP
Title (EN) PEPTIDE HAVING CELL MEMBRANE PERMEABILITY, CONSTRUCT, AND METHOD FOR TRANSPORTING CARGO MOLECULE INTO CELL
(FR) PEPTIDE PRÉSENTANT UNE PERMÉABILITÉ DE LA MEMBRANE CELLULAIRE, CONSTRUCTION ET PROCÉDÉ POUR TRANSPORTER UNE MOLÉCULE CARGO DANS UNE CELLULE
(JA) 細胞膜透過性を有するペプチド、構築物、及び、カーゴ分子を細胞内に輸送する方法
Abstract:
(EN) Provided is a cell-permeating peptide which enables efficient introduction into a cell. A cell-permeating peptide shown below can be produced by introducing a specific cationic proline derivative using nona-arginine having cell membrane permeability as a base.
(FR) L'invention concerne un peptide à perméation cellulaire qui permet l’introduction efficace dans une cellule. Un peptide à perméation cellulaire présenté ci-après peut être obtenu par l'introduction d'un dérivé de proline cationique spécifique en utilisant comme base un peptide non-arginine ayant une perméabilité de la membrane cellulaire.
(JA) 効率的な細胞内導入を可能とする細胞膜透過性ペプチドを提供する。細胞膜透過性を有するノナアルギニンをベースとして、所定のカチオン性プロリン誘導体を導入することにより、下記に示す細胞膜透過性ペプチドが得られる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)