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1. (WO2017134555) DERIVATIVES OF PYRROLOIMIDAZOLE OR ANALOGUES THEREOF WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/134555 International Application No.: PCT/IB2017/050507
Publication Date: 10.08.2017 International Filing Date: 31.01.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/407 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407
condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
EMCURE PHARMACEUTICALS LIMITED [IN/IN]; Emcure House, T-184, M.I.D.C., Bhosari Pune 411026, IN
Inventors:
GURJAR, Mukund Keshav; IN
ROYCHOWDHURY, Abhijit; IN
KHALADKAR, Tushar Pandurang; IN
SAWARGAVE, Sangmeshwar Prabhakar; IN
JANRAO, Ravindra Ashok; IN
KALHAPURE, Vijay Keshav; IN
URUNKAR, Ganesh Devidas; IN
GULLAPALLI, Srinivas; IN
KULATHINGAL, Jayanarayan; IN
LEKKALA, Rammohan Reddy; IN
Priority Data:
20162100359602.02.2016IN
20162102411014.07.2016IN
Title (EN) DERIVATIVES OF PYRROLOIMIDAZOLE OR ANALOGUES THEREOF WHICH ARE USEFUL FOR THE TREATMENT OF INTER ALIA CANCER
(FR) DÉRIVÉS DE PYRROLOIMIDAZOLE OU ANALOGUES DE CEUX-CI UTILES, ENTRE AUTRES, DANS LE TRAITEMENT DU CANCER
Abstract:
(EN) Present invention relates to novel heterocyclic compounds as indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) modulators. Compounds of the present invention inhibit tryptophan degradation by modulating IDO and/or TDO. Formula (I) The invention further relates to the process of their preparation, pharmaceutical composition and their use in modulating the activity of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3- dioxygenase (TDO). The compounds of the invention can be used alone or in combination for the treatment of conditions that benefits from the inhibition of tryptophan degradation.
(FR) La présente invention concerne de nouveaux composés hétérocycliques utilisés comme modulateurs de l'indoléamine 2,3-dioxygénase (IDO) et/ou de la tryptophane 2,3-dioxygénase (TDO). Les composés de la présente invention inhibent la dégradation du tryptophane par la modulation de l'IDO et/ou de la TDO. Formule (I). L'invention concerne en outre le procédé de préparation de ces composés, une composition pharmaceutique ainsi que l'utilisation de ceux-ci pour moduler l'activité de l'indoléamine 2,3-dioxygénase (IDO) et/ou de la tryptophane 2,3-dioxygénase (TDO). Les composés de l'invention peuvent être utilisés seuls ou en combinaison pour traiter des états pathologiques qui bénéficient d'une inhibition de la dégradation du tryptophane.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3011677AU2017215424SG11201806480UMYPI 2018702627EP3400226IL260685
CN109071548US20190031665PH1/2018/501621