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1. (WO2017134476) METHOD FOR THE PRODUCTION OF POMALIDOMIDE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/134476 International Application No.: PCT/HU2017/050002
Publication Date: 10.08.2017 International Filing Date: 19.01.2017
IPC:
C07D 401/04 (2006.01) ,A61K 31/454 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
454
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
Applicants:
EGIS GYÓGYSZERGYÁR ZRT. [HU/HU]; Keresztúri út 30-38. 1106 Budapest, HU
Inventors:
VOLK, Balázs; HU
KÁTAINÉ FADGYAS, Katalin; HU
LUKÁCS, Gyula; HU
TÓTHNÉ LAURITZ, Mária; HU
DANCSÓ, András; HU
KIRÁLY, Imre; HU
PALOTAI, László; HU
KORMÁNY, Róbert; HU
Agent:
KOVÁRI LLC; Attila út 125. 1012 Budapest, HU
Priority Data:
P160005804.02.2016HU
Title (EN) METHOD FOR THE PRODUCTION OF POMALIDOMIDE
(FR) PROCÉDÉ DE PRODUCTION DE POMALIDOMIDE
Abstract:
(EN) The object of the invention relates to a novel group of compounds of general formula 20 that may be used as an intermediate for the production of the pharmaceutical active substance pomalidomide. The object of the invention also relates to a novel, cost-effective, productive method for the production of pomalidomide that can also be implemented on industrial scales via the novel compound of formula 20 according to the invention.
(FR) La présente invention décrit un nouveau groupe de composés de formule générale 20 qui peut être utilisé comme intermédiaire destiné à la production de pomalidomide substance active pharmaceutique. L'objet de l'invention concerne également un nouveau procédé productif rentable destiné à la production de pomalidomide qui peut également être mis en œuvre aux échelles industrielles via le nouveau composé de formule 20 selon l'invention.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Hungarian (HU)
Also published as:
UAa201808784EP3411366EA201891631US20190040037