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1. (WO2017134455) BIOLOGICAL METHODS FOR DIAGNOSING ACTIVE TUBERCULOSIS OR FOR DETERMINING THE RISK OF A LATENT TUBERCULOSIS INFECTION PROGRESSING TO ACTIVE TUBERCULOSIS AND MATERIALS FOR USE THEREIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/134455 International Application No.: PCT/GB2017/050275
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
IMPERIAL INNOVATIONS LIMITED [GB/GB]; 52 Princes Gate Exhibition Road South Kensington London SW7 2PG, GB
Inventors:
LALVANI, Ajit; GB
HOANG, Long; GB
NIAZI, Umar; GB
Agent:
HARDING, Thomas Daniel; GB
Priority Data:
1602142.005.02.2016GB
Title (EN) BIOLOGICAL METHODS FOR DIAGNOSING ACTIVE TUBERCULOSIS OR FOR DETERMINING THE RISK OF A LATENT TUBERCULOSIS INFECTION PROGRESSING TO ACTIVE TUBERCULOSIS AND MATERIALS FOR USE THEREIN
(FR) MÉTHODES BIOLOGIQUES DE DIAGNOSTIC DE TUBERCULOSE ACTIVE OU DE DÉTERMINATION DU RISQUE D'UNE INFECTION LATENTE PAR LA TUBERCULOSE ÉVOLUANT EN TUBERCULOSE ACTIVE ET MATÉRIAUX UTILISABLES DANS CES MÉTHODES
Abstract:
(EN) There is provided methods for diagnosing active tuberculosis (ATB), or for determining the risk of a latent tuberculosis infection (LTBI) progressing to ATB, in an individual comprising or consisting of the steps of: a) providing a sample to be tested from the individual; b) measuring the expression in the test sample of GBP6 and/or BATF2; wherein the expression in the test sample of GBP6 and/or BATF2 is indicative of the presence of active tuberculosis (ATB) in the individual, and/or wherein the expression in the test sample of GBP6 and/or BATF2 is proportional to the risk of a latent TB infection progressing to an active TB infection in the individual. There are also provided binding agents and kits for use in such methods.
(FR) L'invention concerne des méthodes de diagnostic de tuberculose active (ATB), ou de détermination du risque d'une infection latente par la tuberculose (LTBI) évoluant en ATB, chez un sujet, comprenant ou constituées des étapes consistant à : a) fournir un échantillon à tester provenant du sujet ; b) mesurer l'expression dans l'échantillon de test de GBP6 et/ou de BATF2 ; l'expression dans l'échantillon de test de GBP6 et/ou BATF2 étant indicative de la présence de tuberculose active (ATB) chez le sujet, et/ou l'expression dans l'échantillon de test de GBP6 et/ou de BATF2 étant proportionnelle au risque d'une infection latente par la tuberculose évoluant en une infection par la tuberculose active chez le sujet. L'invention concerne également des agents de liaison et des trousses, destinés à être utilisés dans de telles méthodes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3411501US20190055604