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1. (WO2017134197) MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH IMPROVED INTERNALIZATION CHARACTERISTICS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/134197 International Application No.: PCT/EP2017/052335
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
C07K 16/28 (2006.01) ,C07K 16/32 (2006.01) ,A61P 35/00 (2006.01) ,A61K 47/68 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
[IPC code unknown for A61K 47/68]
Applicants:
GENMAB A/S [DK/DK]; Kalvebod Brygge 43 1560 Copenhagen V, DK
Inventors:
DE GOEIJ, Bart; NL
MELIS, Joost; NL
VINK, Tom; NL
TEN NAPEL, Hendrik; NL
BREIJ, Esther; NL
SATIJN, David; NL
PARREN, Paul; NL
Agent:
GENMAB A/S; Kalvebod Brygge 43 1560 Copenhagen V, DK
Priority Data:
PA 2016 0007405.02.2016DK
Title (EN) MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH IMPROVED INTERNALIZATION CHARACTERISTICS
(FR) MOLÉCULE DE LIAISON AUX ANTIGÈNES MULTISPÉCIFIQUE PRÉSENTANT DE MEILLEURES CARACTÉRISTIQUES D'INTERNALISATION
Abstract:
(EN) The present invention relates to a multispecific antigen-binding molecule comprising a first antigen-binding domain and a second antigen-binding domain. The first domain specifically binds a target molecule (T), and the second domain specifically binds an internalizing effector protein (E), the second antigen-binding domain having a dissociation constant (KD) with E of between 10-9 and 10-8 M. The multispecific antigen-binding molecule is useful in a method for treating and/or preventing a cancer.
(FR) La présente invention concerne une molécule de liaison aux antigènes multispécifique comprenant un premier domaine de liaison à l'antigène et un second domaine de liaison à l'antigène. Le premier domaine se lie spécifiquement une molécule cible (T), et le second domaine se lie spécifiquement à une protéine effectrice d'internalisation (E), le second domaine de liaison à l'antigène ayant une constante de dissociation (KD) avec E comprise entre 10-9 et 10-8 M. La molécule de liaison aux antigènes multispécifique est utile dans une méthode de traitement et/ou de prévention d'un cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017214338KR1020180104148EP3411406CN109071658