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1. (WO2017134098) TAU PET IMAGING LIGANDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/134098 International Application No.: PCT/EP2017/052143
Publication Date: 10.08.2017 International Filing Date: 01.02.2017
IPC:
A61K 51/04 (2006.01) ,C07B 59/00 (2006.01) ,C07D 401/14 (2006.01) ,A61K 101/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51
Preparations containing radioactive substances for use in therapy or testing in vivo
02
characterised by the carrier
04
Organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59
Introduction of isotopes of elements into organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
101
Radioactive non-metals
02
Halogens
Applicants:
JANSSEN PHARMACEUTICA NV [BE/BE]; Turnhoutseweg 30 2340 Beerse, BE
Inventors:
MOECHARS, Diederik Willem Elisabeth; BE
ROMBOUTS, Frederik Jan Rita; BE
LEENAERTS, Joseph Elisabeth; BE
ANDRÉS-GIL, José Ignacio; ES
FIERENS, Katleen; BE
CHUPAKHIN, Vladimir; BE
BORMANS, Guy Maurits R.; BE
DECLERCQ, Lieven Denis Herwig; BE
KOLB, Hartmuth; US
ZHANG, Wei; US
Agent:
GARCIA PRIETO, Maria; BE
Priority Data:
16154123.003.02.2016EP
16161466.421.03.2016EP
16183009.605.08.2016EP
16186603.331.08.2016EP
Title (EN) TAU PET IMAGING LIGANDS
(FR) LIGANDS D'IMAGERIE TAU-PET
Abstract:
(EN) The present invention relates to novel, selective radiolabelled tau ligands which are useful for imaging and quantifying tau aggregates, using positron-emission tomography (PET). The invention is also directed to compositions comprising such compounds, to processes for preparing such compounds and compositions, to the use of such compounds and compositions for imaging a tissue or a subject, in vitro or in vivo, and to precursors of said compounds.
(FR) La présente invention concerne de nouveaux ligands tau radiomarqués sélectifs, qui sont utilisés pour l'imagerie et la quantification d'agrégats de protéines tau, par tomographie par émission de positons (TEP). L'invention concerne également des compositions comprenant lesdits composés, des procédés de préparation desdits composés et desdites compositions, l'utilisation desdits composés et desdites compositions pour l'imagerie d'un tissu ou d'un sujet, in vitro ou in vivo, ainsi que des précurseurs desdits composés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017216212CA3010690EP3411083IL260862EA201891726US20190038784