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1. (WO2017134089) CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE MONOFUMARATE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/134089 International Application No.: PCT/EP2017/052121
Publication Date: 10.08.2017 International Filing Date: 01.02.2017
IPC:
C07F 9/6561 (2006.01) ,A61K 31/675 (2006.01) ,A61P 31/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561
containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
Applicants:
SANDOZ AG [CH/CH]; Lichtstrasse 35 4056 Basel, CH
Inventors:
HOTTER, Andreas; AT
LENGAUER, Hannes; AT
Agent:
KLUSCHANZOFF, Harald; DE
ENGLMEIER, Ludwig; DE
Priority Data:
16153952.302.02.2016EP
16166063.419.04.2016EP
Title (EN) CRYSTALLINE FORMS OF TENOFOVIR ALAFENAMIDE MONOFUMARATE
(FR) FORMES CRISTALLINES DU MONOFUMARATE DE TÉNOFOVIR ALAFÉNAMIDE
Abstract:
(EN) The present invention relates to crystalline forms of tenofovir alafenamide monofumarate and methods for their preparation. Furthermore, the invention relates to the use of one or more of the crystalline forms of tenofovir alafenamide monofumarate of the present invention for the preparation of pharmaceutical compositions as well as to pharmaceutical compositions comprising an effective amount of one or more of said forms. The pharmaceutical compositions of the present invention can be used as medicaments, in particular for the treatment and/or prophylaxis of viral infections such as HIV infections.
(FR) La présente invention concerne des formes cristallines du monofumarate de ténofovir alafénamide et leurs procédés de préparation. En outre, l'invention concerne l'utilisation d'une ou de plusieurs des formes cristallines du monofumarate de ténofovir alafénamide de la présente invention servant à la préparation de compositions pharmaceutiques, ainsi que des compositions pharmaceutiques comprenant une quantité efficace d'une ou de plusieurs desdites formes. Les compositions pharmaceutiques de la présente invention peuvent être utilisées en tant que médicaments, en particulier dans le traitement et/ou la prophylaxie d'infections virales telles que les infections à VIH.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3411378