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1. (WO2017133913) REDUCTIVE ALKYLATION OF AMINES WITH ORTHOCARBOXYLIC ACID ESTERS
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Patent claims

1. Process for the N-alkylation of amines or of ammonia by reacting an orthocarboxylic acid ester with an amine or with ammonia and with hydrogen in the presence of a hydrogenation catalyst.

2. Process according to Claim 1 , where the reaction takes place in the presence of an acid.

3. Process according to Claim 2, where the reaction takes place at a molar ratio of acid to the amine used in a range from 0.01 :100 to 10:100.

4. Process according to one of Claims 1 to 3, where the reaction takes place at a molar ratio of hydrogenation catalyst to the amine used in a range from 1 :10 to 1 :100 000.

5. Process according to one of Claims 1 to 4, where the reaction takes place at a hydrogen partial pressure in a range from 0.1 bar to 200 bar.

6. Process according to one of Claims 1 to 5, where the reaction is carried out in a temperature range from 20°C to 200°C.

7. Process according to one of Claims 1 to 6, where the hydrogenation catalyst is a

heterogeneous hydrogenation catalyst.

8. Process according to Claim 7, where the heterogeneous hydrogenation catalyst comprises at least one active metal.

9. Process according to Claim 8, where the active metal is a metal of group VII B and/or VIII B of the Periodic Table of the Elements.

10. Process according to one of Claims 1 to 9, where the reaction takes place in a solvent.

11. Process according to Claim 10, where the solvent is selected from the group consisting of hydrocarbons, chlorohydrocarbons, ethers, esters and alcohols.

12. Process according to one of Claims 1 to 11 , where the reaction is carried out without solvents.