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1. (WO2017133713) APPLICATION OF PHOSPHODIESTERASE 4 INHIBITOR ZL-N-91 IN PREPARATION OF MEDICATIONS FOR LUNG CANCER PROLIFERATION AND METASTASIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133713 International Application No.: PCT/CN2017/078690
Publication Date: 10.08.2017 International Filing Date: 30.03.2017
IPC:
A61K 31/341 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
34
having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341
not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
广州华真医药科技有限公司 GUANGZHOU SINOGEN BIOMEDICAL TECHNOLOGY, LTD [CN/CN]; 中国广东省广州 高新技术开发区科学城科研路3号自编A4栋办公卡位427号 No. 427, A4 Building, No. 3, Science Road Science City, High-tech Development Zone Guangzhou, Guangdong 510663, CN
Inventors:
赵子建 ZHAO, Allan Zijian; CN
巩思嘉 GONG, Sijia; CN
林艳 LIN, Yan; CN
李芳红 LI, Fanghong; CN
李晓曦 LI, Xiaoxi; CN
Agent:
南京苏高专利商标事务所(普通合伙) NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHION); 中国江苏省南京 白下区中山东路198号龙台国际大厦1912室 Room 1912, Longtaiguoji Mansion, No.198, East Zhongshan Street, Baixia District Nanjing, Jiangsu 210005, CN
Priority Data:
201610081083.005.02.2016CN
Title (EN) APPLICATION OF PHOSPHODIESTERASE 4 INHIBITOR ZL-N-91 IN PREPARATION OF MEDICATIONS FOR LUNG CANCER PROLIFERATION AND METASTASIS
(FR) APPLICATION DE ZL-N-91, INHIBITEUR DE PHOSPHODIESTÉRASE 4, DANS LA PRÉPARATION DE MÉDICAMENTS POUR LA PROLIFÉRATION ET LES MÉTASTASES DES CELLULES CANCÉREUSES DU POUMON
(ZH) 磷酸二酯酶4抑制剂ZL-n-91在制备抗肺癌增殖与转移药物中的应用
Abstract:
(EN) Provided is an application of a new phosphodiesterase 4 (PDE4) inhibitor ZL-n-91 for medications for treating lung cancer proliferation and metastasis.
(FR) L'invention concerne l'application d'un nouvel inhibiteur de phosphodiestérase 4 (PDE4), le ZL-n-91, pour des médicaments destinés à traiter la prolifération et les métastases des cellules cancéreuses du poumon. Des courbes de survie chez la souris et des expériences cellulaires in vitro démontrent que l'inhibiteur de phosphodiestérase 4 ZL-n-91 de la présente invention inhibe sensiblement la prolifération et les métastases des cellules cancéreuses du poumon, ce qui prédit que l'inhibiteur de phosphodiestérase 4 ZL-n-91 peut devenir un important objectif de recherche pour la lutte contre la prolifération et les métastases des cellules cancéreuses du poumon, qu'il peut servir de base pour la préparation de médicaments luttant contre la prolifération et les métastases des cellules cancéreuses du poumon, et qu'il peut avoir de bonnes perspectives de développement et d'application.
(ZH) 本发明提供一种新型磷酸二酯酶4(PDE4)抑制剂ZL-n-91在治疗抗肺癌增殖和转移药物中的应用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
AU2017214157EP3412287US20180369188