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1. (WO2017133684) TLR7 AGONIST CRYSTALLINE FORM A, PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133684 International Application No.: PCT/CN2017/072891
Publication Date: 10.08.2017 International Filing Date: 04.02.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 海州区郁州南路369号 No. 369 Yuzhou South Rd., Haizhou District Lianyungang, Jiangsu 222062, CN
Inventors:
丁照中 DING, Zhaozhong; CN
孙飞 SUN, Fei; CN
胡迎虎 HU, Yinghu; CN
周义龙 ZHOU, Yilong; CN
王峥 WANG, Zheng; CN
赵锐 ZHAO, Rui; CN
杨玲 YANG, Ling; CN
Agent:
北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.; 中国北京市 东城区北三环东路36号北京环球贸易中心C座10层 10th Floor, Tower C, Beijing Global Trade Center, 36 North Third Ring Road East, Dongcheng District Beijing 100013, CN
Priority Data:
201610082029.805.02.2016CN
Title (EN) TLR7 AGONIST CRYSTALLINE FORM A, PREPARATION METHOD AND USE THEREOF
(FR) FORME CRISTALLINE A D'UN AGONISTE DE TLR7, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 一种TLR7激动剂的晶型A、其制备方法和用途
Abstract:
(EN) The present invention relates to crystalline form A of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), a method for preparing the crystalline form A, and the use thereof.
(FR) La présente invention concerne une forme cristalline A d'un agoniste de TLR7, 2-butoxy-7-(4-(pyrrolidin-1-ylméthyl)-benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formule I), un procédé de préparation de la forme cristalline A, et son utilisation.
(ZH) 本发明涉及一种TLR7激动剂2-丁氧基-7-(4-(吡咯烷-1-基甲基)苄基)-5H-吡咯并[3,2-d]嘧啶-4-胺(式I)的晶型A、其制备方法及其用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
UAa201809129AU2017215801CA3013518MYPI 2018702703SG11201806683UKR1020180104117
CN108602831IN201817030380EP3412672IL260968BR112018015880US20190040071
EA201891768ID2018/12855PH1/2018/501643