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1. (WO2017133683) TLR7 AGONIST MALEATE SALT, CRYSTALLINE FORMS C, D AND E THEREOF, PREPARATION METHODS AND USES OF MALEATE SALT AND CRYSTALLINE FORMS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133683 International Application No.: PCT/CN2017/072890
Publication Date: 10.08.2017 International Filing Date: 04.02.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 海州区郁州南路369号 No. 369 Yuzhou South Rd., Haizhou District Lianyungang, Jiangsu 222062, CN
Inventors:
丁照中 DING, Zhaozhong; CN
孙飞 SUN, Fei; CN
胡迎虎 HU, Yinghu; CN
周义龙 ZHOU, Yilong; CN
王峥 WANG, Zheng; CN
杨玲 YANG, Ling; CN
Agent:
北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.; 中国北京市 东城区北三环东路36号北京环球贸易中心C座10层 10th Floor, Tower C, Beijing Global Trade Center, 36 North Third Ring Road East, Dongcheng District Beijing 100013, CN
Priority Data:
201610082030.005.02.2016CN
Title (EN) TLR7 AGONIST MALEATE SALT, CRYSTALLINE FORMS C, D AND E THEREOF, PREPARATION METHODS AND USES OF MALEATE SALT AND CRYSTALLINE FORMS
(FR) SEL DE MALÉATE D'AGONISTE DU TLR7, FORMES CRISTALLINES C, D ET E DE CELUI-CI, PROCÉDÉS DE PRÉPARATION ET UTILISATIONS DU SEL DE MALÉATE ET DE SES FORMES CRISTALLINES
(ZH) 一种TLR7激动剂的马来酸盐、其晶型C、晶型D、晶型E及其制备方法和用途
Abstract:
(EN) The present invention relates to a maleate salt of a compound represented by formula I, a method for preparing the salt, a pharmaceutical composition containing the salt, and the use of the salt. The present invention also relates to crystalline forms C, D and E of the maleate salt of the compound represented by formula I, methods for preparing the crystalline forms, crystalline compositions and pharmaceutical compositions containing the crystalline forms, and uses thereof.
(FR) La présente invention concerne un sel de maléate d'un composé représenté par la formule (I), un procédé de préparation de ce sel, une composition pharmaceutique contenant ce sel et l'utilisation de ce sel. La présente invention concerne également les formes cristallines C, D et E du sel de maléate du composé représenté par la formule (I), des procédés de préparation de ces formes cristallines, des compositions cristallines et des compositions pharmaceutiques contenant les formes cristallines ainsi que leurs utilisations.
(ZH) 本发明涉及式I所示化合物的马来酸盐、该盐的制备方法、包含该盐的药物组合物和该盐的用途。本发明还涉及式I所示化合物的马来酸盐的晶型C、晶型D和晶型E;它们的制备方法、包含它们的结晶组合物、药物组合物及用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
UAa201809085AU2017215800MYPI 2018702706SG11201806682TKR1020180104116CN108602830
CA3013682IN201817030377EP3412671IL260965BR112018015881US20190070179
EA201891770ID2018/13211PH1/2018/501644