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1. (WO2017133681) TRICYCLIC COMPOUND FOR BROMODOMAIN-CONTAINING PROTEIN INHIBITOR AND PREPARATION, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133681 International Application No.: PCT/CN2017/072878
Publication Date: 10.08.2017 International Filing Date: 04.02.2017
IPC:
C07D 471/14 (2006.01) ,C07D 471/04 (2006.01) ,A61K 31/4375 (2006.01) ,A61K 31/437 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/12 (2006.01) ,A61P 25/28 (2006.01) ,A61P 29/00 (2006.01) ,A61P 9/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
4375
the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants:
正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 海州区郁州南路369号 No.369 Yuzhou South Rd., Haizhou District Lianyungang, Jiangsu 222062, CN
北京赛林泰医药技术有限公司 CENTAURUS BIOPHARMA CO., LTD. [CN/CN]; 中国北京市 海淀区闵庄路3号16号楼 Building #16, Minzhuang Road #3, Haidian District Beijing 100195, CN
连云港润众制药有限公司 LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. [CN/CN]; 中国江苏省连云港市 连云港经济技术开发区大浦工业区金桥路16号 No.16 Jinqiao Road, Dapu Industry Park Lianyungang Economy and Technology Development Zone Lianyungang, Jiangsu 222069, CN
Inventors:
李继军 LI, Jijun; CN
吴伟 WU, Wei; CN
朱岩 ZHU, Yan; CN
王虎庭 WANG, Huting; CN
赵利嘉 ZHAO, Lijia; CN
何伟男 HE, Weinan; CN
孙颖慧 SUN, Yinghui; CN
彭勇 PENG, Yong; CN
韩永信 HAN, Yongxin; CN
Agent:
北京英赛嘉华知识产权代理有限责任公司 INSIGHT INTELLECTUAL PROPERTY LIMITED; 中国北京市 海淀区知春路甲48号盈都大厦A座19A 19A, Tower A, InDo Building No.48A Zhichun Road, Haidian District Beijing 100098, CN
Priority Data:
201610080167.205.02.2016CN
Title (EN) TRICYCLIC COMPOUND FOR BROMODOMAIN-CONTAINING PROTEIN INHIBITOR AND PREPARATION, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF
(FR) COMPOSÉ TRICYCLIQUE POUR INHIBITEUR DE PROTÉINE CONTENANT UN BROMODOMAINE ET PRÉPARATION, COMPOSITION PHARMACEUTIQUE ET SON UTILISATION
(ZH) 溴区结构域蛋白抑制剂的三环类化合物及其制备、药物组合物和用途
Abstract:
(EN) The present application relates to a compound represented by formula (III) or a pharmaceutically acceptable salt, solvent compound, active metabolite, crystal polymorph, ester, isomer, or prodrug thereof. The application further provides a pharmaceutical composition comprising the compound represented by formula (III) and a use thereof for preparing a bromodomain inhibitor for preventing or treating various diseases, such as inflammation and cancer, related to the bromodomain.
(FR) La présente invention concerne un composé représenté par la formule (III) ou un sel pharmaceutiquement acceptable, un composé de solvant, un métabolite actif, un polymorphe cristallin, un ester, un isomère ou un promédicament de celui-ci. L'invention concerne également une composition pharmaceutique comprenant le composé représenté par la formule (III) et son utilisation dans la préparation d'un inhibiteur de bromodomaine pour prévenir ou traiter diverses maladies, telles que les maladies inflammatoires et le cancer, liées au bromodomaine.
(ZH) 本申请涉及式(III)的化合物或其药学上可接受的盐、溶剂化物、活性代谢物、多晶型物、酯、异构体或前药,包含式(III)的化合物的药物组合物及其作为溴区结构域抑制剂用于预防或治疗与其相关的各种疾病如炎症和癌症等的用途。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
CN108770356EP3412669US20190040063