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1. (WO2017133542) PHARMACEUTICAL COMPOSITION COMPRISING PYRIDOPYRIMIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133542 International Application No.: PCT/CN2017/072213
Publication Date: 10.08.2017 International Filing Date: 23.01.2017
IPC:
A61K 31/519 (2006.01) ,A61K 9/20 (2006.01) ,A61K 47/38 (2006.01) ,A61K 47/32 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN/CN]; 中国江苏省连云港市 经济技术开发区昆仑山路7号 No.7 Kunlunshan Road,Economic and Technological Development Zone, Lianyungang, Jiangsu 222047, CN
Inventors:
卢韵 LU, Yun; CN
张新华 ZHANG, Xinhua; CN
丁欢 DING, Huan; CN
张代美 ZHANG, Daimei; CN
Agent:
北京戈程知识产权代理有限公司 GE CHENG & CO., LTD.; 中国北京市 东城区东长安街1号东方广场东三办公楼19层程伟 CHENG, David W. Level 19, Tower E3, The Towers, Oriental Plaza, No.1, East Chang An Avenue, Dongcheng District Beijing 100738, CN
Priority Data:
201610080476.X04.02.2016CN
Title (EN) PHARMACEUTICAL COMPOSITION COMPRISING PYRIDOPYRIMIDINE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT UN DÉRIVÉ PYRIDOPYRIMIDINE OU UN SEL DE QUALITÉ PHARMACEUTIQUE DE CE DERNIER
(ZH) 一种含有吡啶并嘧啶类衍生物或其可药用盐的药物组合物
Abstract:
(EN) The present invention discloses a pharmaceutical composition comprising a pyridopyrimidine derivative or a pharmaceutically acceptable salt thereof. Specifically, the composition comprises 6-acetyl-8- cyclopentyl-5-methyl-2-{[5-(piperidin-4-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one or a pharmacologically acceptable salt thereof, and a disintegrant. The disintegrant is a disintegrant with no metallic element. The composition dissolves rapidly. The preparation process of the pharmaceutical composition of the present invention is simple and more suitable for industrial-scale production.
(FR) La présente invention concerne une composition pharmaceutique comprenant un dérivé pyridopyrimidine ou un sel de qualité pharmaceutique de ce dernier. Spécifiquement, la composition comprend du 6-acétyl-8-cyclopentyl-5-méthyl-2-{[5-(pipéridine-4-yl)pyridine-2-yl]amino}pyrido[2,3-d]pyrimidine-7(8H)-one ou un sel de qualité pharmaceutique de ce dernier, et un désagrégeant. Le désagrégeant est un désagrégeant ne comprenant aucun élément métallique. La composition se dissout rapidement. Le procédé de préparation de la composition pharmaceutique de la présente invention est simple et plus approprié pour une production à l'échelle industrielle.
(ZH) 本发明公开了一种含有吡啶并嘧啶类衍生物或其可药用盐的药物组合物。具体而言,所述的组合物包含6-乙酰基-8-环戊基-5-甲基-2-((5-(哌啶-4-基)吡啶-2-基)氨基)吡啶并[2,3-d]嘧啶-7(8H)-酮或其药理学上可接受的盐,以及崩解剂,所述崩解剂为不含金属元素的崩解剂,所述组合物溶出迅速。本发明的药物组合物制备工艺简单,更适合工艺化大生产。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
CN107405350