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1. (WO2017133419) DRUG-LOADED MICROSPHERE AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133419 International Application No.: PCT/CN2017/070980
Publication Date: 10.08.2017 International Filing Date: 12.01.2017
IPC:
A61K 9/16 (2006.01) ,A61K 31/513 (2006.01) ,A61K 47/32 (2006.01) ,A61K 47/34 (2017.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
16
Agglomerates; Granulates; Microbeadlets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
513
having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
三捷生物科技(北京)有限公司 3J BIOTECHNOLOGY (BEIJING) CO., LTD [CN/CN]; 中国北京市 大兴区经济技术开发区科创六街88号院6号楼3单元202室 Room 202, Unit 3, Building 6, No.88 Kechuang 6th Street, Economic and Technological Development Zone Daxing District Beijing 101111, CN
Inventors:
张悦 ZHANG, Yue; CN
梁捷 LIANG, Jie; CN
杜建英 DU, Jianying; CN
Agent:
北京润平知识产权代理有限公司 RUNPING&PARTNERS; 中国北京市 海淀区北四环西路9号,银谷大厦515室 Suite 515,Yingu Mansion,No.9 Beisihuanxilu, Haidian District Beijing 100190, CN
Priority Data:
201610076925.303.02.2016CN
Title (EN) DRUG-LOADED MICROSPHERE AND PREPARATION METHOD AND USE THEREOF
(FR) MICROSPHÈRE CHARGÉE EN MÉDICAMENT, ET PROCÉDÉ DE PRÉPARATION ET UTILISATION DE CETTE DERNIÈRE
(ZH) 一种载药微球及其制备方法和应用
Abstract:
(EN) Disclosed is a method for preparing a drug-loaded microsphere, the microsphere prepared using the method and the use thereof, wherein the method comprises: mixing a surfactant and water to prepare the aqueous phase; mixing the drug and drug carrier with the polymer material, a first solvent and a second solvent to prepare the oil phase; and adding the oil phase into the aqueous phase and mixing same, wherein the first solvent and the second solvent are different, and the second solvent and the first solvent are miscible, the second solvent is at least one of a C1-C3 alcohol, a C1-C3 fatty acid, a C1-C3 fatty acid ester, a C1-C2 ether and acetonitrile, and the amount of the first solvent is greater than the amount of the second solvent.
(FR) L'invention concerne un procédé de préparation d'une microsphère chargée en médicament, la microsphère préparée par ce procédé et l'utilisation de cette dernière, le procédé consistant : à mélanger un agent tensioactif et de l'eau pour préparer la phase aqueuse ; à mélanger le médicament et l'excipient du médicament avec le matériau polymère, un premier solvant et un second solvant pour préparer la phase huileuse ; et à ajouter la phase huileuse dans la phase aqueuse et mélanger ces dernières, le premier solvant et le second solvant étant différents, et le second solvant et le premier solvant étant miscibles, le second solvant étant au moins l'un des éléments du groupe constitué par les alcools en C1-C3, les acide gras en C1-C3, les esters d'acide gras en C1-C3, les éthers en C1-C2 et l'acétonitrile, et la quantité du premier solvant étant supérieure à la quantité du second solvant.
(ZH) 一种制备载药微球的方法,该方法制备的微球及应用,包括:将表面活性剂与水混合,制得水相;将药物、药物载体用聚合物材料、第一溶剂和第二溶剂混合,制得油相;将油相加入到水相中进行混合;其中,第一溶剂与第二溶剂不同,且第二溶剂与第一溶剂互溶,所述第二溶剂为C1-C3的醇、C1-C3的脂肪酸、C1-C3的脂肪酸酯、C1-C2的醚和乙腈中的至少一种,第一溶剂的用量大于第二溶剂的用量。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)