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1. (WO2017133258) 1H-INDAZOLE DERIVATIVE AND USE THEREOF AS IDO INHIBITOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133258 International Application No.: PCT/CN2016/099845
Publication Date: 10.08.2017 International Filing Date: 23.09.2016
IPC:
C07D 231/56 (2006.01) ,A61K 31/416 (2006.01) ,A61P 25/28 (2006.01) ,A61P 27/12 (2006.01) ,A61P 31/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 31/18 (2006.01) ,A61P 35/00 (2006.01) ,A61P 25/24 (2006.01) ,A61P 3/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54
condensed with carbocyclic rings or ring systems
56
Benzopyrazoles; Hydrogenated benzopyrazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
416
condensed with carbocyclic ring systems, e.g. indazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
12
for cataracts
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
西华大学 XIHUA UNIVERSITY [CN/CN]; 中国四川省成都市 金牛区土桥金周路999号 No.999 Jinzhou road Chengdu, Sichuan 610039, CN
Inventors:
钱珊 QIAN, Shan; CN
王周玉 WANG, Zhouyu; CN
杨羚羚 YANG, Lingling; CN
李国菠 LI, Guobo; CN
赖朋 LAI, Peng; CN
刘思言 LIU, Siyan; CN
李会周 LI, Huizhou; CN
Agent:
成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); 中国四川省成都市 高新区衣冠庙邮局A-42号信箱 The Yiguanmiao Post Office Box A-42, Hi-Tech Zone Chengdu, Sichuan 610041, CN
Priority Data:
201610081017.304.02.2016CN
201610560610.615.07.2016CN
201610831550.719.09.2016CN
Title (EN) 1H-INDAZOLE DERIVATIVE AND USE THEREOF AS IDO INHIBITOR
(FR) DÉRIVÉ DE 1H-INDAZOLE ET UTILISATION CORRESPONDANTE COMME INHIBITEUR DE L'IDO
(ZH) 1H-吲唑类衍生物及其作为IDO抑制剂的用途
Abstract:
(EN) Disclosed in is a 1H-indazole derivative as shown in formula (A), and also disclosed is a method for preparing the compound and the use thereof as an IDO inhibitor. The compound of the present invention can be used for preventing and/or treating a variety of diseases, such as Alzheimer's disease, cataracts, cellular immune activation-related infections, autoimmune diseases, AIDS, cancers, depression, tryptophan metabolic abnormalities and so on.
(FR) La présente invention décrit un dérivé de 1H-indazole tel que présenté dans la formule (A), et décrit également un procédé de préparation du composé et l'utilisation correspondante comme inhibiteur de l'IDO. Le composé de la présente invention peut être utilisé de manière à prévenir et/ou traiter diverses maladies, telles que la maladie d'Alzheimer, la cataracte, les infections liées à une activation immunitaire cellulaire, les maladies auto-immunes, le SIDA, les cancers, la dépression, les anomalies métaboliques liées au tryptophane et ainsi de suite.
(ZH) 本发明公开了式(A)所示的1H-吲唑类衍生物,还公开了所述化合物的制备方法和作为IDO抑制剂的用途。本发明的化合物可以用于预防和/或治疗多种疾病,如阿尔茨海默病、白内障、细胞免疫激活相关的感染、自身免疫性疾病、艾滋病、癌症、抑郁症或色氨酸代谢异常等。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)