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1. (WO2017133175) ENGINEERED MAMMALIAN CELLS FOR CANCER THERAPY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/133175 International Application No.: PCT/CN2016/087855
Publication Date: 10.08.2017 International Filing Date: 30.06.2016
IPC:
A61K 48/00 (2006.01) ,C12N 5/16 (2006.01) ,C12N 5/22 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12
Fused cells, e.g. hybridomas
16
Animal cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
12
Fused cells, e.g. hybridomas
22
Human cells
Applicants:
NANJING LEGEND BIOTECH CO., LTD. [CN/CN]; No.6 Building of Nanjing Life Science Town, No.568 Longmian Avenue, Jiangning District Nanjing, Jiangsu 211100, CN
Inventors:
FAN, Xiaohu; CA
ZHANG, Fangliang; CN
ZHUANG, Qiuchuan; CN
WANG, Pingyan; CN
WANG, Lin; CN
HAO, Jiaying; CN
YANG, Lei; CN
Agent:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE; 821 Yufei Plaza 42 Dongzhimenwai Avenue Dongcheng District Beijing 100027, CN
Priority Data:
PCT/CN2016/07348904.02.2016CN
Title (EN) ENGINEERED MAMMALIAN CELLS FOR CANCER THERAPY
(FR) CELLULES MAMMIFÈRES GÉNÉTIQUEMENT MODIFIÉES POUR THÉRAPIE ANTICANCÉREUSE
Abstract:
(EN) Provided are pharmaceutical compositions comprising an engineered mammalian cell comprising a heterologous nucleic acid encoding an immunomodulator (such as immune checkpoint inhibitor). Further provided are methods of treating cancer using the pharmaceutical composition either singly or in combination with other technologies, such as Chimeric Antigen Receptor (CAR) or recombinant T cell receptor (TCR) modified T cell immunotherapy.
(FR) L'invention concerne des compositions pharmaceutiques comprenant une cellule mammifère génétiquement modifiée comprenant un acide nucléique hétérologue codant pour un immunomodulateur (tel qu'un inhibiteur des points de contrôle immunitaires). L'invention concerne en outre des méthodes de traitement du cancer utilisant une telle composition pharmaceutique seule ou en combinaison avec d'autres technologies, telles que l'immunothérapie faisant appel aux lymphocytes T modifiés pour exprimer des récepteurs antigéniques chimériques (CAR) ou des récepteurs des lymphocytes T (TCR) recombinés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)