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1. (WO2017132772) ANTIBODIES AND ELISAS FOR ALPHA KLOTHO
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/132772 International Application No.: PCT/CA2017/050127
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
C12N 15/13 (2006.01) ,A61K 39/395 (2006.01) ,C07K 16/00 (2006.01) ,C07K 16/18 (2006.01) ,G01N 33/573 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
573
for enzymes or isoenzymes
Applicants:
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO [CA/CA]; Banting Institute Heritage Building 100 College Street, Suite 413 Toronto, Ontario M5G 1L5, CA
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/CA]; The University of Texas Health Science Center at Houston 201 West 7th Street Austin, Texas 78701, US
Inventors:
SIDHU, Sachdev S.; CA
BARKER, Sarah, L.; CA
MOE, Orson, W.; US
KURO-O, Makoto; JP
PASTOR, Johanne; US
Agent:
BERESKIN & PARR LLP/S.E.N.C.R.L., S.R.L.; 40th Floor 40 King Street West Toronto, Ontario M5H 3Y2, CA
Priority Data:
62/290,77603.02.2016US
Title (EN) ANTIBODIES AND ELISAS FOR ALPHA KLOTHO
(FR) ANTICORPS ET KITS ELISA POUR LE DOSAGE DE LA PROTÉINE ALPHA KLOTHO
Abstract:
(EN) An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.
(FR) L'invention concerne un anticorps et/ou un fragment de liaison correspondant, l'anticorps et/ou le fragment de liaison correspondant comprenant une région variable de chaîne légère et une région variable de chaîne lourde, la région variable de chaîne légère comprenant une région déterminant la complémentarité (CDR) CDR-L3 et la région variable de chaîne lourde comprenant CDR-H1, CDR-H2 et CDR-H3, les séquences d'acides aminés de ladite CDR comprenant une ou plusieurs des séquences présentées ci-dessous : CDR-L3 ; choisies parmi l'une quelconque des séquences SEQ ID NO : 123, 126-130, 142, 148 ou 149 ; CDR-H1 : SEQ ID NO : 121 ou 124 ; CDR-H2 ; SEQ ID NO : 122 ou 125 ; et/ou CDR-H3 : choisies parmi l'une quelconque des séquences SEQ ID NO : 196 à 226.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3012873EP3411482US20190041402