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1. (WO2017132536) USE OF HISTONE DEACETYLASE INHIBITORS FOR ENHANCING IMMUNOTHERAPIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/132536 International Application No.: PCT/US2017/015389
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
A61K 39/395 (2006.01) ,A61K 45/06 (2006.01) ,A61K 31/4406 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4406
only substituted in position 3, e.g. zimeldine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
Applicants:
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION [US/US]; 518 Indiana Ave. Indianapolis, Indiana 46202, US
Inventors:
PILI, Roberto; US
Agent:
BOETTLER, Jeannie M.; US
GILL, Brian J.; US
CARLSON, Judith L.; US
CRONIN, James J.; US
SELLERS, Andrea F.; US
SLICER, Penny R.; US
TASSI, Elizabeth A.; US
TURNER, Colin W.; US
KAZMIERSKI, Steven T.; US
EIDSON, Bradley S.; US
MEHTA, Samir R.; US
Priority Data:
62/288,12128.01.2016US
Title (EN) USE OF HISTONE DEACETYLASE INHIBITORS FOR ENHANCING IMMUNOTHERAPIES
(FR) UTILISATION D'INHIBITEURS D'HISTONE DÉSACÉTYLASE POUR AMÉLIORER DES IMMUNOTHÉRAPIES
Abstract:
(EN) Compositions including combinations of class I histone deacetylase (HDAC) inhibitors and programmed cell death protein 1 (PD-1) inhibitors for enhancing antitumor activity are disclosed. Further disclosed are methods of administering these compositions as immunotherapies for suppressing regulatory T cells in renal cell carcinoma.
(FR) La présente invention concerne des compositions comprenant des combinaisons d’inhibiteurs d'histone désacétylase (HDAC) de classe 1 et d’inhibiteurs de la protéine 1 de mort cellulaire programmée (PD-1) pour améliorer l'activité antitumorale. L'invention concerne en outre des procédés d'administration de ces compositions en tant qu’immunothérapies pour supprimer les lymphocytes T régulateurs dans le carcinome à cellules rénales.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017211383CA3013047KR1020180104122EP3407913IN201817028323CN108883179
IL260765BR112018015291US20190030011