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1. (WO2017132508) TREATMENT OF LUNG CANCER USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND ANOTHER ANTI-CANCER AGENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/132508 International Application No.: PCT/US2017/015333
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
C07K 16/28 (2006.01) ,A61K 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Rt. 206 & Province Line Road Princeton, New Jersey 08543, US
Inventors:
NATHAN, Faith; US
Agent:
KIM, Ji-Eun; US
BANOWIT, Donald R.; US
BEZOS, Salvador M.; US
CALVO, Paul A.; US
CIMBALA, Michele A.; US
COLLER III, Richard D.; US
CORNWELL, David K.S.; US
COVERT, John M.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GOLDSTEIN, Jorge A.; US
GORDON, Lori A.; US
HELVEY, Jeffery T.; US
HICKS, Ross; US
HOLOUBEK, Michelle K.; US
HOOVER, Kenley K.; US
JACKMAN, Peter A.; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MCGROARTY, John P.; US
MESSINGER, Michael V.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph; US
NANNENGA-COMBS, Bonnie; US
PICKARD, Byron L.; US
RAY, Michael B.; US
ROSE GILLENTINE, Marsha; US
RYGIEL, Mark W.; US
SHEA, JR., Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STEFFE, Eric K.; US
STERLING, Deborah A.; US
STERNE, Robert Greene; US
WRIGHT, Jon E.; US
MCGROARTY, John P.; US
LONGSWORTH, Gaby L.; US
CAMARCE, Christian; US
CONKLIN, Kyle; US
BODENSTEIN, Matthew; US
Priority Data:
62/287,71727.01.2016US
Title (EN) TREATMENT OF LUNG CANCER USING A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND ANOTHER ANTI-CANCER AGENT
(FR) TRAITEMENT DU CANCER DU POUMON À L'AIDE D'UNE COMBINAISON D'UN ANTICORPS ANTI-PD-1 ET D'UN AUTRE AGENT ANTICANCÉREUX
Abstract:
(EN) This disclosure provides a method for treating a subject afflicted with a lung cancer, which method comprises administering to the subject therapeutically effective amounts of: (a) an anticancer agent which is an antibody or an antigen-binding portion thereof that specifically binds to a Programmed Death-1 (PD-1) receptor and inhibits PD-1 activity which can be administered by infusion for less than 60 minutes; and, optionally, (b) another anti-cancer agent which is administered by infusion for less than 90 minutes. The other anti-cancer agent can be an anti- Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) antibody.
(FR) L'invention concerne une méthode de traitement d'un sujet souffrant d'un cancer du poumon, comprenant l'administration au sujet de doses thérapeutiquement efficaces : (a) d'un agent anticancéreux qui est un anticorps ou un fragment de celui-ci se liant à l'antigène, qui se lie spécifiquement à un récepteur-1 de mort cellulaire programmée (PD-1) et inhibe l'activité de PD-1, et qui peut être administré par perfusion sur une durée de moins de 60 minutes; et éventuellement, (b) d'un autre agent anticancéreux administré par perfusion sur une durée de moins de 90 minutes. Cet autre agent anticancéreux peut être un anticorps ayant pour cible l'antigène-4 des lymphocytes T cytotoxiques (CTLA-4).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CN108602892KR1020180101584EP3408296