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1. (WO2017132486) COMPOSITIONS AND METHODS FOR TARGETING CANCER STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/132486 International Application No.: PCT/US2017/015301
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
C07K 16/44 (2006.01) ,A61K 9/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
44
against material not provided for elsewhere
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
Applicants:
SIAMAB THERAPEUTICS, INC. [US/US]; 90 Bridge Street Suite 100 Newton, Massachusetts 02458, US
THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, Massachusetts 02114, US
Inventors:
EAVARONE, David A.; US
BEHRENS, Jeffrey; US
PRENDERGAST, Jillian M.; US
RUEDA, Bo R.; US
FOSTER, Rosemary; US
STARBUCK, Kristen D.; US
Agent:
WARD, Donna T.; US
SULLIVAN, Christopher P.; US
Priority Data:
62/287,67927.01.2016US
62/293,87211.02.2016US
62/345,47003.06.2016US
Title (EN) COMPOSITIONS AND METHODS FOR TARGETING CANCER STEM CELLS
(FR) COMPOSITIONS ET MÉTHODES DE CIBLAGE DE CELLULES SOUCHES CANCÉREUSES
Abstract:
(EN) Compositions and methods for treating ovarian cancer are provided. Methods include combined treatment with chemotherapeutic agents and anti-STn antibodies. Chemotherapy resistant ovarian cancer cells may be reduced. Chemotherapy resistant ovarian cancer cells may include cancer stem cells.
(FR) La présente invention concerne des compositions et des méthodes pour traiter un cancer de l'ovaire. Les méthodes comprennent le traitement combiné avec des agents chimiothérapeutiques et des anticorps anti-STn. Les cellules ovariennes cancéreuses résistantes à la chimiothérapie peuvent être réduites. Les cellules ovariennes cancéreuses résistantes à la chimiothérapie peuvent comprendre des cellules souches cancéreuses.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20190031780