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1. (WO2017132419) ACOUSTIC SEPARATION OF T CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/132419 International Application No.: PCT/US2017/015197
Publication Date: 03.08.2017 International Filing Date: 26.01.2017
IPC:
C12M 1/00 (2006.01) ,B01D 21/28 (2006.01) ,A61M 1/36 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
21
Separation of suspended solid particles from liquids by sedimentation
28
Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
M
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
1
Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
36
Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
Applicants:
FLODESIGN SONICS, INC. [US/US]; 380 Main Street Wilbraham, MA 01095, US
Inventors:
LIPKENS, Bart; US
GILMANSHIN, Rudolf; US
DUTRA, Brian; US
ROSS-JOHNSRUD, Benjamin; US
Agent:
KLEIN, Richard M.; US
Priority Data:
15/139,24826.04.2016US
62/286,98426.01.2016US
Title (EN) ACOUSTIC SEPARATION OF T CELLS
(FR) SÉPARATION ACOUSTIQUE DE CELLULES T
Abstract:
(EN) Acoustophoretic devices and methods for separating biological cells (particularly T-cells) from other fluids / materials using multi-dimensional acoustic standing waves are disclosed. The devices include an inlet, at least two outlets, and a flow chamber having an ultrasonic transducer-reflector pair. Specifically, T cells, B cells, or NK cells can be separated from other blood components. A dual-pass acoustophoretic system including two acoustophoretic devices arranged in series and fluidly connected to one another is also illustrated. Means for pre-chilling the mixture prior to separation in the devices or system can be used to improve retention, concentration, and clarification and to prevent outgassing.
(FR) La présente invention concerne des dispositifs et des procédés acoustophorétiques de séparation de cellules biologiques (particulièrement de cellules T) d’autres liquides/matériaux au moyen d'ondes stationnaires acoustiques multi-dimensionnelles. Les dispositifs comprennent un orifice d’entrée, au moins deux orifices de sortie, et une chambre d’écoulement présentant une paire de transducteur-réflecteur ultrasonores. Spécifiquement, les cellules T, les cellules B, ou les cellules NK peuvent être séparées d'autres constituants sanguins. Un système acoustophorétique à double passage comprenant deux dispositifs acoustophorétiques disposés en série et raccordés de manière fluidique l’un à l’autre est également illustré. La présente invention décrit un moyen de pré-refroidissement du mélange avant la séparation dans les dispositifs ou système afin d’améliorer la rétention, la concentration, et la clarification et d’empêcher le dégazage.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)