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1. (WO2017131500) NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/131500 International Application No.: PCT/KR2017/001034
Publication Date: 03.08.2017 International Filing Date: 31.01.2017
IPC:
C07C 233/64 (2006.01) ,A61K 31/166 (2006.01) ,A23L 33/10 (2016.01) ,C07D 241/04 (2006.01) ,C07B 55/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
64
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
[IPC code unknown for A23L 33/10]
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
241
Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
B
GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
55
Racemisation; Complete or partial inversion
Applicants:
계명대학교 산학협력단 INDUSTRY ACADEMIC COOPERATION FOUNDATION KEIMYUNG UNIVERSITY [KR/KR]; 대구시 달서구 달구벌대로 1095 1095, Dalgubeol-daero Dalseo-gu Daegu 42601, KR
Inventors:
서영호 SEO, Young Ho; KR
Agent:
특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM; 서울시 금천구 가산디지털1로151 이노플렉스1차 601호 #601 Innoplex 1 cha, 151Gasandigital 1-ro Geumcheon-gu Seoul 08506, KR
Priority Data:
10-2016-001162229.01.2016KR
10-2016-001162629.01.2016KR
Title (EN) NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF
(FR) NOUVEAU COMPOSÉ AYANT UNE ACTIVITÉ INHIBITRICE DE HSP90 OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI, ET UTILISATION MÉDICALE DE CELUI-CI
(KO) HSP90 억제 활성을 갖는 신규 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도
Abstract:
(EN) The present invention relates to: a novel compound having an HSP90 inhibitory activity or a pharmaceutically acceptable salt thereof; and a medical use thereof. A composition, of the present invention, containing a dihydroxyphenyl-based compound or a benzamide-based compound, which is the novel compound having HSP90 inhibitory activity, can effectively inhibit HSP90, and thus could be useful as a pharmaceutical composition for preventing or treating any one HSP90-mediated disease selected from the group consisting of cancer, degenerative neurological disorders and viral infections, or as a dietary supplement for preventing or alleviating HSP90-mediated diseases.
(FR) La présente invention concerne : un nouveau composé ayant une activité inhibitrice de HSP90 ou un sel pharmaceutiquement acceptable de celui-ci ; et une utilisation médicale de celui-ci. Une composition de la présente invention, contenant un composé à base de dihydroxyphényle ou un composé à base de benzamide, qui est le nouveau composé ayant une activité inhibitrice de HSP90, peut inhiber efficacement HSP90, et peut donc être utile en tant que composition pharmaceutique pour prévenir ou traiter une maladie quelconque médiée par HSP90 choisie dans le groupe constitué du cancer, de troubles neurologiques dégénératifs et d'infections virales, ou en tant que complément alimentaire pour prévenir ou atténuer des maladies médiées par HSP90.
(KO) HSP90 억제 활성을 갖는 신규 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도에 관한 것으로, 본 발명의 HSP90 억제 활성을 갖는 신규 화합물인 디히드록시페닐(dihydroxyphenyl)계 화합물 또는 벤즈아미드계 화합물을 포함하는 조성물은 HSP90을 효과적으로 억제할 수 있으므로, 암 질환, 퇴행성 신경질환 및 바이러스 감염증으로 이루어진 군에서 선택된 어느 하나의 HSP90 매개 질환 예방 또는 치료용 약학 조성물, 또는 HSP90 매개 질환 예방 또는 개선용 건강기능식품으로 유용하게 사용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)
Also published as:
CN108884021US20190031620