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1. (WO2017131298) COMBINATION OF CROSS-LINKED HYALURONIC ACIDS AND METHOD OF PREPARING THE SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/131298 International Application No.: PCT/KR2016/005819
Publication Date: 03.08.2017 International Filing Date: 01.06.2016
IPC:
C08B 37/08 (2006.01) ,A61K 47/36 (2006.01) ,A61K 9/00 (2006.01) ,A61K 31/728 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
B
POLYSACCHARIDES; DERIVATIVES THEREOF
37
Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
08
Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726
Glycosaminoglycans, i.e. mucopolysaccharides
728
Hyaluronic acid
Applicants:
HANMI PHARM. CO., LTD. [KR/KR]; 214, Muha-ro, Paltan-myeon Hwaseong-si Gyeonggi-do 18536, KR
Inventors:
CHOI, Sung Chul; KR
KIM, Hyun Il; KR
YANG, Ki Young; KR
PARK, Hyo Seung; KR
LEE, Back Ho; KR
Agent:
Y.P.LEE, MOCK & PARTNERS; 12F Daelim Acrotel, 13 Eonju-ro 30-gil Gangnam-gu Seoul 06292, KR
Priority Data:
10-2016-001184329.01.2016KR
10-2016-001251901.02.2016KR
Title (EN) COMBINATION OF CROSS-LINKED HYALURONIC ACIDS AND METHOD OF PREPARING THE SAME
(FR) COMBINAISON D'ACIDES HYALURONIQUES RÉTICULÉS ET SON PROCÉDÉ DE PRÉPARATION
Abstract:
(EN) Provided are a method of preparing a cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa, the method including cross-linking hyaluronic acid with an epoxy-based cross-linking agent having at least two epoxy functional groups in an ethanol-containing aqueous alkaline; a method of preparing a cross-linked hyaluronic acid having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa, the method including cross-linking the cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa with an epoxy-based cross-linking agent having at least two epoxy functional groups in an aqueous alkaline solution; and a combination of cross-linked hyaluronic acids including the cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa and the cross-linked hyaluronic acid having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa.
(FR) La présente invention concerne un procédé de préparation d'un acide hyaluronique réticulé ayant une élasticité d'environ 50 à environ 200 Pa et une viscosité d'environ 20 à environ 100 Pa, le procédé comprenant la réticulation de l'acide hyaluronique avec un agent de réticulation à base d’époxy comportant au moins deux groupes fonctionnels époxy dans une solution alcaline aqueuse contenant de l'éthanol ; un procédé de préparation d'un acide hyaluronique réticulé ayant une élasticité d'environ 400 à environ 800 Pa et une viscosité d’environ 40 à environ 100 Pa, le procédé comprenant la réticulation de l'acide hyaluronique réticulé ayant une élasticité d'environ 50 à environ 200 Pa et une viscosité d'environ 20 à environ 100 Pa avec un agent de réticulation à base d’époxy comportant au moins deux groupes fonctionnels époxy dans une solution alcaline aqueuse ; et une combinaison d'acides hyaluroniques réticulés comprenant l'acide hyaluronique réticulé ayant une élasticité d'environ 50 à environ 200 Pa et une viscosité d'environ 20 à environ 100 Pa et l'acide hyaluronique réticulé ayant une élasticité d'environ 400 à environ 800 Pa et une viscosité comprise entre environ 40 et environ 100 Pa.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20180215840CN108602898