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1. (WO2017131214) TRANSDERMALLY ABSORBABLE COMPOSITION HAVING CONTROLLED RELEASE OF WATER-SOLUBLE ACTIVE INGREDIENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/131214 International Application No.: PCT/JP2017/003067
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
A61K 47/08 (2006.01) ,A61K 47/06 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/14 (2017.01) ,A61K 47/34 (2017.01) ,A61K 47/44 (2017.01) ,A61K 9/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
14
Esters of carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
44
Oils, fats or waxes according to more than one of groups A61K47/02-A61K47/42109
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
Applicants:
日産化学株式会社 NISSAN CHEMICAL CORPORATION [JP/JP]; 東京都中央区日本橋二丁目5番1号 5-1, Nihonbashi 2-chome, Chuo-ku, Tokyo 1036119, JP
国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP/JP]; 福岡県福岡市東区箱崎六丁目10番1号 6-10-1, Hakozaki, Higashi-ku, Fukuoka-shi, Fukuoka 8128581, JP
Inventors:
小野 文靖 ONO Fumiyasu; JP
後藤 雅宏 GOTO Masahiro; JP
平田 修 HIRATA Osamu; JP
岩間 武久 IWAMA Takehisa; JP
Agent:
特許業務法人 津国 TSUKUNI & ASSOCIATES; 東京都千代田区麹町5-3-1 麹町ビジネスセンター Kojimachi Business Center, 5-3-1, Kojimachi, Chiyoda-ku, Tokyo 1020083, JP
山村 大介 YAMAMURA Daisuke; JP
Priority Data:
2016-01597329.01.2016JP
Title (EN) TRANSDERMALLY ABSORBABLE COMPOSITION HAVING CONTROLLED RELEASE OF WATER-SOLUBLE ACTIVE INGREDIENT
(FR) COMPOSITION ABSORBABLE PAR VOIE TRANSDERMIQUE PERMETTANT LA LIBÉRATION CONTRÔLÉE D'UN PRINCIPE ACTIF HYDROSOLUBLE
(JA) 水溶性有効成分の放出が制御された経皮吸収組成物
Abstract:
(EN) The present invention addresses the problem of providing a method for increasing the transdermal absorption of a water-soluble drug in a simple manner without relying on the formation of a prodrug of the water-soluble drug by organic synthesis. The present invention relates to: a complex which is formed from a water-soluble active ingredient and a fat-soluble compound having an aldehyde group through an interaction capable of being dissociated in water; a transdermally absorbable composition comprising the complex, a transdermal absorption controlling agent and a fat-soluble medium; and a method for controlling the release of the water-soluble active ingredient from the complex in skin.
(FR) La présente invention cherche à résoudre le problème qui est de fournir une méthode permettant d'augmenter l'absorption transdermique d'un médicament hydrosoluble d'une façon simple et sans nécessiter la préparation d'un promédicament du médicament hydrosoluble par synthèse organique. La présente invention concerne : un complexe qui est préparé à partir d'un principe actif hydrosoluble et d'un composé liposoluble possédant un groupe aldéhyde lié par une liaison qui peut être rompue en présence d'eau ; une composition qui peut être absorbée par voie transdermique et comprend le complexe, un agent de contrôle de l'absorption transdermique et une substance liposoluble ; et une méthode permettant de contrôler la libération du principe actif hydrosoluble depuis complexe vers la peau.
(JA) 本発明は、有機合成によるプロドラッグ化によらずに水溶性薬剤の経皮吸収性を簡便に高めるための方法を提供することを目的とする。 本発明は、水溶性有効成分とアルデヒド基を有する脂溶性化合物とにより、水中で解離し得る相互作用を介して形成された、複合体;前記複合体、経皮吸収制御剤、及び脂溶性媒体を含む、経皮吸収組成物;ならびに前記複合体からの前記水溶性有効成分の皮膚中での放出を制御する方法に関する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020180104120EP3409291CN108883066US20190030166