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1. (WO2017131208) PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/131208 International Application No.: PCT/JP2017/003059
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
A61K 31/7088 (2006.01) ,A61K 31/7105 (2006.01) ,A61K 31/713 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
東レ株式会社 TORAY INDUSTRIES, INC. [JP/JP]; 東京都中央区日本橋室町2丁目1番1号 1-1, Nihonbashi-Muromachi 2-chome, Chuo-ku, Tokyo 1038666, JP
Inventors:
宮野 敦子 MIYANO Atsuko; JP
須藤 裕子 SUDO Hiroko; JP
高山 愛子 TAKAYAMA Aiko; JP
荒井 大河 ARAI Taiga; JP
Agent:
平木 祐輔 HIRAKI Yusuke; JP
藤田 節 FUJITA Takashi; JP
小瀬村 暁子 KOSEMURA Akiko; JP
Priority Data:
2016-01437928.01.2016JP
2016-12432823.06.2016JP
Title (EN) PHARMACEUTICAL COMPOSITION FOR TREATING AND/OR PREVENTING CANCER
(FR) COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT ET/OU LA PRÉVENTION DU CANCER
(JA) 癌の治療及び/又は予防用医薬組成物
Abstract:
(EN) Provided is a new pharmaceutical composition for treating and/or preventing cancer, the active ingredient of said pharmaceutical composition being a polynucleotide derived from various cancer-related miRNA. Further provided are a combination drug combining said pharmaceutical composition with a separate antitumor drug, and a method for carrying out treatment or prevention on a subject who has cancer using said pharmaceutical composition or combination drug. The present invention pertains to a pharmaceutical composition for treating and/or preventing cancer, said pharmaceutical composition containing, as an active ingredient, a polynucleotide containing a base sequence represented by SEQ ID NO: 1, or a base sequence represented by SEQ ID NO: 1 in which one base has been substituted (if at least a portion of the polynucleotide is DNA, uracil in the region corresponding to the DNA in the base sequence is replaced by thymine).
(FR) La présente invention concerne une nouvelle composition pharmaceutique pour le traitement et/ou la prévention du cancer, le principe actif de ladite composition pharmaceutique étant un polynucléotide dérivé de divers ARNmi associés au cancer. L'invention concerne en outre un médicament combiné associant à ladite composition pharmaceutique un médicament antitumoral séparé, et une méthode pour mettre en oeuvre le traitement ou la prévention chez le patient atteint de cancer en utilisant ladite composition pharmaceutique ou le médicament combiné. La présente invention concerne une composition pharmaceutique pour le traitement et/ou la prévention du cancer, ladite composition pharmaceutique contenant, comme principe actif, un polynucléotide contenant une séquence de base représentée par SEQ ID NO : 1, ou une séquence de base représentée par SEQ ID NO : 1 dans laquelle une base a été substituée (si au moins une partie du polynucléotide est de l'ADN, l'uracile situé dans la région correspondant à l'ADN dans la séquence de base est remplacé par la thymine).
(JA) 本発明は、癌と関連する様々なmiRNAを由来とするポリヌクレオチドを有効成分とする新たな癌の治療及び/又は予防用医薬組成物、この医薬組成物と別の抗腫瘍剤との組み合わせ医薬品、並びに、これらの医薬組成物又は組み合わせ医薬品を用いて癌をもつ被検体を治療又は予防する方法を提供する。本発明は、配列番号1で表される塩基配列又は配列番号1で表される塩基配列において1個の塩基が置換した塩基配列を含むポリヌクレオチドを有効成分として含む、癌の治療及び/又は予防用医薬組成物(但し前記ポリヌクレオチドの少なくとも一部がDNAである場合、前記塩基配列中のDNAに相当する領域のウラシルはチミンに読み替える)に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP3409281JPWO2017131208US20190046551