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1. (WO2017131144) LITHOCHOLIC ACID DERIVATIVE HAVING VITAMIN D ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/131144 International Application No.: PCT/JP2017/002902
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
C07J 9/00 (2006.01) ,A61K 31/575 (2006.01) ,A61P 17/00 (2006.01) ,A61P 19/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 43/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
9
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
国立大学法人お茶の水女子大学 OCHANOMIZU UNIVERSITY [JP/JP]; 東京都文京区大塚2丁目1番1号 2-1-1, Otsuka, Bunkyo-ku, Tokyo 1128610, JP
国立大学法人 東京医科歯科大学 NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY [JP/JP]; 東京都文京区湯島1-5-45 1-5-45, Yushima, Bunkyo-ku, Tokyo 1138510, JP
Inventors:
棚谷 綾 TANATANI Aya; JP
佐々木 晴江 SASAKI Harue; JP
川崎 波留 KAWASAKI Haru; JP
影近 弘之 KAGECHIKA Hiroyuki; JP
増野 弘幸 MASUNO Hiroyuki; JP
Agent:
特許業務法人特許事務所サイクス SIKS & CO.; 東京都中央区京橋一丁目8番7号 京橋日殖ビル8階 8th Floor, Kyobashi-Nisshoku Bldg., 8-7, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031, JP
Priority Data:
2016-01401228.01.2016JP
Title (EN) LITHOCHOLIC ACID DERIVATIVE HAVING VITAMIN D ACTIVITY
(FR) DÉRIVÉ D'ACIDE LITHOCHOLIQUE POSSÉDANT L'ACTIVITÉ DE LA VITAMINE D
(JA) ビタミンD活性を有するリトコール酸誘導体
Abstract:
(EN) The objective of the present invention is to provide: a novel lithocholic acid derivative having vitamin D activity; and a pharmaceutical product, a vitamin D receptor activator and a prophylactic and/or therapeutic agent for vitamin D receptor-related diseases, each of which contains the lithocholic acid derivative. The present invention provides a lithocholic acid derivative which has a hydroxyalkyl group in the 3-position, a salt thereof or a prodrug thereof.
(FR) L'objet de la présente invention est de fournir : un nouveau dérivé d'acide lithocholique possédant l'activité de la vitamine D ; et un produit pharmaceutique, un activateur de récepteur de la vitamine D et un agent prophylactique et/ou thérapeutique pour des maladies associées au récepteur de la vitamine D, contenant chacun ledit dérivé d'acide lithocholique. La présente invention concerne un dérivé d'acide lithocholique qui comprend un groupe hydroxyalkyle en position 3, un sel de celui-ci ou un promédicament de celui-ci.
(JA) 本発明の課題は、ビタミンD活性を有する新規なリトコール酸誘導体、並びに上記リトコール酸誘導体を含む医薬、ビタミンD受容体活性化剤及びビタミンD受容体関連疾患の予防及び/又は治療剤を提供することである。本発明によれば、3位にヒドロキシアルキル基を有するリトコール酸誘導体、その塩、又はそのプロドラッグが提供される。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)