Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2017131127) NOVEL BISPHOSPHONIC ACID COMPOUND
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/131127 International Application No.: PCT/JP2017/002855
Publication Date: 03.08.2017 International Filing Date: 27.01.2017
IPC:
C07F 9/38 (2006.01) ,A61K 31/663 (2006.01) ,A61P 9/00 (2006.01) ,A61P 9/10 (2006.01) ,A61P 19/08 (2006.01) ,A61P 39/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
662
Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
663
Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
39
General protective or antinoxious agents
Applicants:
株式会社富士薬品 FUJIYAKUHIN CO., LTD. [JP/JP]; 埼玉県さいたま市大宮区桜木町4-383 4-383, Sakuragi-cho, Omiya-ku, Saitama-shi, Saitama 3309508, JP
Inventors:
小橋 精一 KOBASHI, Seiichi; JP
青柳 吉宣 AOYAGI, Yoshinobu; JP
加藤 宏茂 KATO, Hiroshige; JP
徳山 竜光 TOKUYAMA, Ryuko; JP
芦澤 直樹 ASHIZAWA, Naoki; JP
石田 紘一 ISHIDA, Koichi; JP
松本 浩二 MATSUMOTO, Koji; JP
Agent:
特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; 東京都中央区日本橋人形町1丁目3番8号 沢の鶴人形町ビル Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013, JP
Priority Data:
2016-02740529.01.2016JP
Title (EN) NOVEL BISPHOSPHONIC ACID COMPOUND
(FR) NOUVEAU COMPOSÉ D'ACIDE BISPHOSPHONIQUE
(JA) 新規ビスホスホン酸化合物
Abstract:
(EN) Provided are: a novel bisphosphonic acid compound which exhibits prominent inhibitory activity against ectopic calcification, or a salt thereof; and a pharmaceutical composition containing the compound or salt thereof. The bisphosphonic acid compound or pharmaceutically acceptable salt thereof is represented by general formula (1). [In the formula, the ------ part represents a single bond or a double bond, A represents a saturated cyclic hydrocarbon, or a saturated heterocycle that contains a sulfur atom or an oxygen atom, and R1 and R2 each independently represent an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an aryloxy group, a haloalkoxy group, a haloalkyl group, a halogen atom, or a hydrogen atom.]
(FR) L'invention concerne un nouveau composé d'acide bisphosphonique qui présente une activité inhibitrice importante contre la calcification ectopique, ou un sel correspondant ; et une composition pharmaceutique comprenant le composé ou le sel correspondant. Le composé d'acide bisphosphonique ou le sel pharmaceutiquement acceptable correspondant est représenté par la formule générale (1). [Dans la formule, la partie ------ représente une simple liaison ou une double liaison, A représente un hydrocarbure cyclique saturé, ou un hétérocycle saturé qui comprend un atome de soufre ou un atome d'oxygène, et R1 et R2 représentent chacun indépendamment un groupe alkyle, un groupe alcényle, un groupe alcynyle, un groupe alcoxy, un groupe aryloxy, un groupe halogénoalcoxy, un groupe halogénoalkyle, un atome d'halogène ou un atome d'hydrogène.]
(JA) 異所性石灰化に対して顕著な抑制作用を有する新規ビスホスホン酸化合物、又はその塩、及びこれらを含有する医薬組成物の提供。 下記一般式(1)[式中、------部分は単結合又は二重結合を示し、Aは飽和環状炭化水素、又は硫黄原子若しくは酸素原子を含む飽和複素環を示し、R及びRは、それぞれ独立にアルキル基、アルケニル基、アルキニル基、アルコキシ基、アリールオキシ基、ハロアルコキシ基、ハロアルキル基、ハロゲン原子、水素原子を示す]で表されるビスホスホン酸化合物、又はその薬学上許容される塩。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
JPWO2017131127AR107472AU2017211464CA3012957MYPI 2018702485SG11201806125U
CN108473518ID2018/11381KR1020180111791IN201817026848EP3409679IL260581
US20190002482BR112018015552PH1/2018/501586