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1. (WO2017130756) THERAPEUTIC DRUG AGAINST INTERVERTEBRAL DISK DEGENERATION, TARGETING ENDOPLASMIC RETICULUM STRESS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/130756 International Application No.: PCT/JP2017/001149
Publication Date: 03.08.2017 International Filing Date: 16.01.2017
IPC:
A61K 45/00 (2006.01) ,A61K 31/519 (2006.01) ,A61K 31/713 (2006.01) ,A61P 19/02 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
学校法人 慶應義塾 KEIO UNIVERSITY [JP/JP]; 東京都港区三田二丁目15番45号 15-45, Mita 2-chome, Minato-ku, Tokyo 1088345, JP
Inventors:
中村 雅也 NAKAMURA Masaya; JP
松本 守雄 MATSUMOTO Morio; JP
藤田 順之 FUJITA Nobuyuki; JP
藤井 武 FUJII Takeshi; JP
Agent:
白形 由美子 SHIRAKATA Yumiko; JP
Priority Data:
2016-01126325.01.2016JP
Title (EN) THERAPEUTIC DRUG AGAINST INTERVERTEBRAL DISK DEGENERATION, TARGETING ENDOPLASMIC RETICULUM STRESS
(FR) MÉDICAMENT THÉRAPEUTIQUE CONTRE LA DÉGÉNÉRESCENCE DU DISQUE INTERVERTÉBRAL, CIBLANT LE STRESS DU RÉTICULUM ENDOPLASMIQUE
(JA) 小胞体ストレスを標的とする椎間板変性症に対する治療薬
Abstract:
(EN) The present invention has shown that endoplasmic reticulum stress correlates with intervertebral disk degeneration, and that an endoplasmic reticulum stress reduction agent, particularly, a PERK inhibitor can ameliorate intervertebral disk degeneration, and backache and other disorders resulting therefrom. In addition, provided is a method for screening a therapeutic drug against intervertebral disk degeneration, the method using, as an index, a change of molecules involved in the NF-κB signal transduction system or the PERK pathway.
(FR) La présente invention a montré que le stress du réticulum endoplasmique est corrélé à la dégénérescence du disque intervertébral, et qu'un agent qui diminue le stress du réticulum endoplasmique, en particulier un inhibiteur de la PERK, peut réduire la dégénérescence du disque intervertébral, et le mal de dos et autres troubles qui en résultent. De plus, l'invention concerne un procédé de criblage de médicaments thérapeutiques contre la dégénérescence du disque intervertébral, le procédé utilisant comme indicateur une modification des molécules impliquées dans le système de transduction du signal NF-κB ou la voie PERK.
(JA) 小胞体ストレスが椎間板変性症と相関があることを明らかにしたことから、小胞体ストレス低減剤、特にPERK阻害剤が椎間板変性症、これに起因する腰痛その他の疾患を改善し得ることを示した。また、PERK経路、又はNF-κBシグナル伝達系の分子の変化を指標とする椎間板変性症の治療薬のスクリーニング方法を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)