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1. WO2017129987 - BOTANICAL COMPOSITIONS OF SALVIA OFFICINALIS WITH ACTIVITY IN EXTENDING CHRONOLOGICAL LIFESPAN AND METHODS OF USE

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Publication Number WO/2017/129987
Publication Date 03.08.2017
International Application No. PCT/GB2017/050209
International Filing Date 27.01.2017
IPC
A61K 36/537 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
537Salvia (sage)
A61P 25/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 43/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 2236/15
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
10Preparation or pretreatment of starting material
15involving mechanical treatment, e.g. chopping up, cutting or grinding
A61K 2236/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
10Preparation or pretreatment of starting material
17involving drying, e.g. sun-drying or wilting
A61K 2236/31
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
31involving untreated material, e.g. fruit juice or sap obtained from fresh plants
A61K 2236/333
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
33involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
333using mixed solvents, e.g. 70% EtOH
A61K 2236/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
A61K 2236/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
50Methods involving additional extraction steps
51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Applicants
  • SIBELIUS LIMITED [GB]/[GB]
Inventors
  • LEYLAND, Peter Anthony
  • AKOULITCHEV, Alexandre
  • VERSLYPE, Antoine
  • CAIGER, Stephen
Agents
  • CREASE, Devanand
  • BAKER, Philip
  • CALDWELL, Judith
  • CALLAGHAN, Mark
  • AHMAD, Sheikh
  • CUMMINGS, Sean
  • DISTEFANO, Luigi
  • FOUNTAIN, Sullivan
  • HOPLEY, Joanne
  • JOHNSTONE, Edward
  • KEHOE, Laura
  • KENT, Peter
  • LAWRENCE, Richard
  • MCDOUGALL, Robert
  • MOORE, Michael
  • RICHARDSON, Mark
  • SMART, Jessica
  • WEAL, Emily
Priority Data
1601520.827.01.2016GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BOTANICAL COMPOSITIONS OF SALVIA OFFICINALIS WITH ACTIVITY IN EXTENDING CHRONOLOGICAL LIFESPAN AND METHODS OF USE
(FR) COMPOSITIONS BOTANIQUES DE SALVIA OFFICINALIS À ACTIVITÉ PROLONGEANT LA DURÉE DE VIE CHRONOLOGIQUE ET PROCÉDÉS D'UTILISATION
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Abstract
(EN) Compositions comprising a nutritionally or pharmaceutically effective dosage of an extract of Salvia officinalis and an acceptable carrier are provided. The compositions show particular potential in the treatment of age-related pathologies in humans or animals. The extracts are obtained from varieties and cultivars of Salvia officinalis that possess a unique chemical fingerprint that includes unusually low thujone content in the leaf. When tested in C. elegans screening assays compositions that comprise the extract elicit an increase in mean chronological lifespan (CLS)in the C. elegans population of at least 10%.
(FR) L'invention concerne des compositions comprenant une dose efficace sur le plan nutritionnel ou pharmaceutique d'un extrait de Salvia officinalis et un excipient acceptable. Les compositions présentent des possibilités particulières pour le traitement de pathologies liées à l'âge chez l'homme ou l'animal. Les extraits sont obtenus à partir de variétés et de cultivars de Salvia officinalis possédant une empreinte chimique unique de teneur en thuyone de la feuille exceptionnellement basse. Lors de dosages de criblage de C. elegans, les compositions comprenant l'extrait induisent une augmentation de la durée de vie chronologique (CLS) moyenne de la population de C. elegans d'au moins 10 %.
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