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1. (WO2017129662) METHOD FOR DETECTION OF GENE MUTATIONS COMPRISING THE DETECTION OF DNA FROM EXTRACELLULAR VESICLES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/129662 International Application No.: PCT/EP2017/051620
Publication Date: 03.08.2017 International Filing Date: 26.01.2017
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
FUNDACION DE INVESTIGACION HM HOSPITALES [ES/ES]; Plaza Conde Valle Suchill 2 28015 Madrid, ES
Inventors:
AYUSO SACIDO, Angel; ES
BELDA INIESTA, Cristobal; ES
CARRION NAVARRO, Josefa; ES
GARCIA ROMERO, Noemí; ES
Agent:
PONS ARIÑO, Ángel; ES
Priority Data:
16382028.526.01.2016EP
Title (EN) METHOD FOR DETECTION OF GENE MUTATIONS COMPRISING THE DETECTION OF DNA FROM EXTRACELLULAR VESICLES
(FR) PROCÉDÉ DE DÉTECTION DE MUTATIONS DE GÈNE COMPRENANT LA DÉTECTION D’ADN À PARTIR DE VÉSICULES EXTRACELLULAIRES
Abstract:
(EN) The present invention describes a method for detecting gene mutations and/or minority alleles comprising extraction the DNA from the total extracellular vesicles isolated from a liquid sample of a subject and amplifying the region of the DNA wherein the gene mutations and/or minority alleles are located by means of a method for enrichment. Preferably the invention refers a method of prognosis of glioma patients by the detection of mutations from IDH1 in serum extracellular vesicles.
(FR) La présente invention décrit un procédé de détection de mutations de gène et/ou d’allèles minoritaires comprenant l’extraction de l’ADN de vésicules extracellulaires totales isolées d’un échantillon de liquide d’un sujet et l’amplification de la région de l’ADN où les mutations de gène et/ou les allèles minoritaires sont localisés à l’aide d’un procédé d’enrichissement. De préférence, l’invention désigne un procédé de prognostic de patients atteints de gliome par la détection de mutations à partir d’IDH1 dans des vésicules extracellulaires sériques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)