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1. (WO2017129195) METHODS FOR MODULATING INTESTINAL MICROBIOTA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/129195 International Application No.: PCT/DK2017/050017
Publication Date: 03.08.2017 International Filing Date: 26.01.2017
Chapter 2 Demand Filed: 27.06.2017
IPC:
A61K 38/00 (2006.01) ,A61K 38/17 (2006.01) ,C07K 14/47 (2006.01) ,A23L 33/00 (2016.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
[IPC code unknown for A23L 33]
Applicants:
DEFENSIN THERAPEUTICS APS [DK/DK]; c/o COBIS Ole Maaloesvej 3 2200 Copenhagen, DK
Inventors:
NORDKILD, Peter; DK
WEHKAMP, Jan; DE
KJÆRULFF, Søren; DK
Agent:
HØIBERG P/S; Adelgade 12 1304 Copenhagen K, DK
Priority Data:
PA 2016 7004126.01.2016DK
PA 2016 7048301.07.2016DK
Title (EN) METHODS FOR MODULATING INTESTINAL MICROBIOTA
(FR) PROCÉDÉS DE MODULATION DU MICROBIOTE INTESTINAL
Abstract:
(EN) The present invention relates to methods for modulating the intestinal microbiota by administering one or more defensins and/or GLP-1/GLP-1 analogs and methods for prevention or treatment of gut inflammation by oral administration of one or more defensins. GLP-1 analogs such as Liraglutide, as well as mammalian and poultry alfa and beta defensins can cause a change in the composition of the microbiota and metabolome in the intestine and can therefore be used to treat or prevent gut inflammation, colorectal cancer, metabolic syndrome, obesity, prediabetes and diabetes or as lean growth promoters in the meat production.
(FR) La présente invention concerne des procédés de modulation du microbiote intestinal par administration d’une ou plusieurs défensines et/ou GLP-1/analogues de GLP-1 et des procédés de prévention ou de traitement de l’inflammation intestinale par administration orale d’une ou plusieurs défensines. Des analogues de GLP-1 tels que le liraglutide, ainsi que des alpha et bêta-défensines de mammifère et de volaille peuvent causer un changement de la composition du microbiote et du métabolome dans l'intestin et, par conséquent, peuvent être utilisés pour traiter ou prévenir l'inflammation intestinale, le cancer, le syndrome métabolique, l'obésité, le prédiabète et le diabète ou en tant que promoteurs de croissance de tissu maigre dans la production de viande.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017212534CA3012711SG11201805954WCN108778309KR1020180121489EP3407905
BR112018015170US20190111107