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1. (WO2017129125) STEROID DERIVATIVE FXR AGONIST
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/129125 International Application No.: PCT/CN2017/072567
Publication Date: 03.08.2017 International Filing Date: 25.01.2017
IPC:
C07J 43/00 (2006.01) ,C07J 31/00 (2006.01) ,C07J 33/00 (2006.01) ,C07J 9/00 (2006.01) ,A61K 31/575 (2006.01) ,A61K 31/58 (2006.01) ,A61P 1/16 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/06 (2006.01) ,A61P 3/10 (2006.01) ,A61P 9/10 (2006.01) ,A61P 13/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
43
Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
31
Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
33
Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta[a]hydrophenanthrene skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
9
Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
575
substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
56
Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58
containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
02
of urine or of the urinary tract, e.g. urine acidifiers
Applicants:
正大天晴药业集团股份有限公司 CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国江苏省连云港市 海州区郁州南路369号 No.369 Yuzhou South Rd., Haizhou District Lianyungang, Jiangsu 222062, CN
Inventors:
贺海鹰 HE, Haiying; CN
肖华玲 XIAO, Hualing; CN
李鹏 LI, Peng; CN
杜春艳 DU, Chunyan; CN
罗志 LUO, Zhi; CN
陈曙辉 CHEN, Shuhui; CN
Agent:
上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE; 中国上海市 小木桥路681号外经大厦21楼 21st Floor, SFECO Mansion, No.681 Xiaomuqiao Road Shanghai 200032, CN
Priority Data:
201610061293.328.01.2016CN
201610331759.718.05.2016CN
Title (EN) STEROID DERIVATIVE FXR AGONIST
(FR) AGONISTE STÉROÏDIEN DU RÉCEPTEUR FXR (RÉCEPTEUR FARNESOÏDE X)
(ZH) 甾体类衍生物FXR激动剂
Abstract:
(EN) The present invention relates to a compound represented by formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to applications thereof in the preparation of drugs for treating FXR related diseases.
(FR) La présente invention concerne un composé représenté par la formule (I), un tautomère ou un sel pharmaceutiquement acceptable de celui-ci, ainsi que des applications dudit composé dans la préparation de médicaments destinés au traitement de maladies associées au récepteur FXR.
(ZH) 本发明涉及式(Ⅰ)所示化合物、其互变异构体或其药学上可接受的盐,并涉及其在制备治疗FXR相关疾病药物中的应用。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
CA3012396SG11201806348PAU2017213032MYPI 2018702594IN201847030473KR1020180100703
ID2018/10759EP3409684IL260795CN109071593BR112018015474PH1/2018/550120
EA201891690