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1. (WO2017129116) PYRROLOPYRIMIDINE FIVE-MEMBERED AZACYCLIC DERIVATIVE AND APPLICATION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/129116 International Application No.: PCT/CN2017/072535
Publication Date: 03.08.2017 International Filing Date: 25.01.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 29/00 (2006.01) ,A61P 19/02 (2006.01) ,A61P 17/06 (2006.01) ,A61P 7/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
Applicants:
杭州华东医药集团生物医药有限公司 HANGZHOU HUADONG MEDICINE GROUP BIOPHARMACEUTICAL CO., LTD. [CN/CN]; 中国浙江省杭州市 拱墅区莫干山路866号 No.866 Monganshan Road, Gongshu District Hangzhou, Zhejiang 310011, CN
殷建明 YIN, Jianming [US/US]; US
Inventors:
殷建明 YIN, Jianming; US
吕裕斌 LV, Yubin; CN
李邦良 LI, Bangliang; CN
Agent:
苏州创元专利商标事务所有限公司 SUZHOU CREATOR PATENT & TREADMARK AGENCY LTD.; 中国江苏省苏州市 干将西路93号 No.93 Ganjiang West Road Suzhou, Jiangsu 215002, CN
Priority Data:
201610052851.X26.01.2016CN
Title (EN) PYRROLOPYRIMIDINE FIVE-MEMBERED AZACYCLIC DERIVATIVE AND APPLICATION THEREOF
(FR) DÉRIVÉ AZACYCLIQUE À CINQ CHAÎNONS PYRROLOPYRIMIDINE ET APPLICATION CORRESPONDANTE
(ZH) 吡咯嘧啶五元氮杂环衍生物及其应用
Abstract:
(EN) The present invention relates to a pyrrolopyrimidine five-membered azacyclic derivative as a novel JAK kinase inhibitor, and use thereof in a preparation of a pharmaceutical product for preventing and/or treating an indication related to a JAK kinase function. The pyrrolopyrimidine five-membered azacyclic derivative of the invention is an ideal JAK kinase inhibitor with a high potency, and can be used to treat or prevent diseases such as rheumatoid arthritis, polycythemia vera, psoriasis, primary thrombocytosis, myelofibrosis, and the like.
(FR) La présente invention concerne un dérivé azacyclique à cinq chaînons pyrrolopyrimidine comme nouvel inhibiteur de JAK kinase, et l'utilisation correspondante dans une préparation d'un produit pharmaceutique destiné à la prévention et/ou au traitement d'une indication concernant une fonction de la JAK kinase. Le dérivé dérivé azacyclique à cinq chaînons pyrrolopyrimidine de l'invention est un inhibiteur de kinase JAK idéal d'une puissance élevée, et peut être utilisé de manière à traiter ou prévenir des maladies telles que la polyarthrite rhumatoïde, la maladie de vaquez, le psoriasis, la thrombocytémie essentielle, la myélofibrose et analogues.
(ZH) 本发明涉及一种新型的JAK激酶抑制剂吡咯嘧啶五元氮杂环衍生物及其在制备预防和/或治疗与JAK激酶功能有关的适应症的药物中的用途。本发明的吡咯嘧啶五元氮杂环衍生物是理想的高效JAK激酶抑制剂,可用于治疗或预防类风湿性关节炎、真性红细胞增多症、银屑病、原发性血小板增多症和骨髓纤维化等疾病。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
EP3409673US20190040068