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1. (WO2017129061) APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/129061 International Application No.: PCT/CN2017/071898
Publication Date: 03.08.2017 International Filing Date: 20.01.2017
IPC:
C07D 317/60 (2006.01) ,C07C 235/34 (2006.01) ,C07D 295/192 (2006.01) ,A61K 31/36 (2006.01) ,A61K 31/4525 (2006.01) ,A61K 31/496 (2006.01) ,A61K 31/165 (2006.01) ,A61K 31/4453 (2006.01) ,A61P 25/22 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
317
Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08
having the hetero atoms in positions 1 and 3
44
ortho- or peri-condensed with carbocyclic rings or ring systems
46
condensed with one six-membered ring
48
Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
50
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
60
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
32
the carbon skeleton containing six-membered aromatic rings
34
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16
acylated on ring nitrogen atoms
18
by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
182
Radicals derived from carboxylic acids
192
from aromatic carboxylic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
357
having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
36
Compounds containing methylenedioxyphenyl groups, e.g. sesamin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
4525
containing a five-membered ring with oxygen as a ring hetero atom
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4453
only substituted in position 1, e.g. propipocaine, diperodon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
Applicants:
天士力医药集团股份有限公司 TASLY PHARMACEUTICAL GROUP CO., LTD. [CN/CN]; 中国天津市 北辰区普济河东道2号天士力现代中药城 Tasly Modern TCM Garden Pu Jihe East Road No.2, Beichen District Tianjin 300410, CN
Inventors:
韩民 HAN, Min; CN
马晓慧 MA, Xiaohui; CN
周王谊 ZHOU, Wangyi; CN
刘雁勇 LIU, Yanyong; CN
李彦川 LI, Yanchuan; CN
王晶 WANG, Jing; CN
周水平 ZHOU, Shuiping; CN
孙鹤 SUN, He; CN
朱永宏 ZHU, Yonghong; CN
Agent:
北京君尚知识产权代理事务所(普通合伙) BEIJING JOYSHINE INTELLECTUAL PROPERTY OFFICE; 中国北京市 海淀区北四环西路68号左岸工社1316-1317室 Room 1316-1317, Left Bank Community Building No. 68 Beisihuanxilu Road, Haidian District Beijing 100080, CN
Priority Data:
201610053180.927.01.2016CN
Title (EN) APPLICATION OF SUBSTITUTED CINNAMAMIDE DERIVATIVES IN PREPARATION OF ANTI-ANXIETY MEDICATIONS
(FR) APPLICATION DE DÉRIVÉS SUBSTITUÉS DU CINNAMAMIDE DANS LA PRÉPARATION DE MÉDICAMENTS CONTRE L'ANXIÉTÉ
(ZH) 取代桂皮酰胺衍生物在制备抗焦虑药物中的应用
Abstract:
(EN) Disclosed is an application of substituted cinnamamide derivatives in the preparation of Anti-anxiety medications, the substituted cinnammide derivatives are compounds having the structure of formula (I) or pharmaceutically acceptable salts thereof, wherein, R1 is –H, -OH, -F, -Cl, -Br, -I, -OCH 3, -OCF 3, -OCHF 2, -OCH 2F, -CF 3, -CHF 2, -CH 2F, -CH 3, -CH 3CH 2, -CF 3CH 2, -CN, -NO 2, -NH 2 or -COOR 5; R 2 is H, C 1-C 10 linear alkyl, C 3-C 10 branched alkyl, C 3-C 10 cyclic alkyl, C 1-C 10 hydroxyalkyl or a N-substituted piperazine-derived group; or R 2 is a group forming with adjacent Y a tetrahydropyrrolyl group, a piperidyl group or a cyclohexanimido group.
(FR) L'invention concerne une application de dérivés substitués du cinnamamide dans la préparation de médicaments contre l'anxiété, les dérivés substitués du cinnamamide étant des composés possédant la structure présentée dans la formule (I) ou des sels de qualité pharmaceutique de ces derniers, où R1 est -H, -OH, -F, -Cl, -Br, -I, -OCH3, -OCF3, -OCHF2, -OCH2F, -CF3, -CHF2, -CH2F, -CH3, -CH3CH2, -CF3CH2, -CN, -NO2, -NH2 ou -COOR5 ; R2 est H, un alkyle linéaire en C1-C10, un alkyle ramifié en C3-C10, un alkyle cyclique en C3-C10, un hydroxyalkyle en C1-C10 ou un groupe N-substitué dérivé de la pipérazine ; ou R2 est un groupe formant avec le Y adjacent un groupe tetrahydropyrrolyle, un groupe pipéridyle ou un groupe cyclohexanimide.
(ZH) 一种取代桂皮酰胺衍生物在制备抗焦虑药物中的应用,所述的取代桂皮酰胺衍生物为式(Ⅰ)结构的化合物或其可药用盐,具体如下:式中:R 1为-H、-OH、-F、-Cl、-Br、-I、-OCH 3、-OCF 3、-OCHF 2、-OCH 2F、-CF 3、-CHF 2、-CH 2F、-CH 3、-CH 3CH 2、-CF 3CH 2、-CN、-NO 2、-NH 2或-COOR 5;R 2为H、C 1-C 10直链烃基、C 3-C 10支链烃基、C 3-C 10环烃基、C 1-C 10羟烷基或N-取代哌嗪衍生基团;或R 2为与相邻的Y形成四氢吡咯基、哌啶基或环己亚胺基的基团。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)
Also published as:
AU2017213007CA3007870IL260068IN201817019013KR1020180103846EP3409664
US20190046500