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1. (WO2017128837) NEW DACLATASVIR CRYSTAL FORM AND PREPARATION METHOD THEREFOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/128837 International Application No.: PCT/CN2016/107526
Publication Date: 03.08.2017 International Filing Date: 28.11.2016
IPC:
C07D 403/14 (2006.01) ,A61K 31/4178 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4178
not condensed and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
上海众强药业有限公司 SHANGHAI FOREFRONT PHARMCEUTICAL CO., LTD [CN/CN]; 中国上海市 浦东新区张江高科技园区法拉第路249号7幢底层西侧楼面 1st Floor, West Wing, Building 7, 249 Faladi Road, Zhangjiang Hi-Tech Park Pudong New Area Shanghai 201203, CN
Inventors:
李巍 LI, Wei; CN
任毅 REN, Yi; CN
王琼 WANG, Qiong; CN
朱燕燕 ZHU, Yanyan; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room No.106, Building No.1 Universal High-Tech Plaza 958 Zhen Bei Road Putuo District, Shanghai 200333, CN
Priority Data:
201610050738.825.01.2016CN
Title (EN) NEW DACLATASVIR CRYSTAL FORM AND PREPARATION METHOD THEREFOR
(FR) NOUVELLE FORME CRISTALLINE DU DACLATASVIR ET PROCÉDÉ POUR LA PRÉPARER
(ZH) 达卡他韦新晶型及其制备方法
Abstract:
(EN) Provided are a new daclatasvir crystal form and a preparation method therefor. Specifically, bis-p-tosylates, bis-phosphates and bis-hydrobromates of the crystalline daclatasvir are disclosed. The new crystal form has better physico-chemical properties, thereby facilitating the quality control and preparation application of daclatasvir.
(FR) La présente invention concerne une nouvelle forme cristalline du daclatasvir et un procédé pour la préparer, l'invention concernant spécifiquement des bis-p-tosylates, des bis-phosphates et des bis-bromhydrates du daclatasvir cristallin. La nouvelle forme cristalline possède de meilleures propriétés physico-chimiques, ce qui facilite le contrôle qualité et l'utilisation en formulation du daclatasvir.
(ZH) 本发明提供了达卡他韦新晶型及其制备方法,具体地,本发明披露了结晶性的达卡他韦的双对甲苯磺酸盐、双磷酸盐和双氢溴酸盐,所述的新晶型具备较好的理化性质,有利于达卡他韦的质量控制和制剂应用。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)