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1. WO2017125557 - CRYSTALLINE ERAVACYCLINE BIS-HYDROCHLORIDE

Publication Number WO/2017/125557
Publication Date 27.07.2017
International Application No. PCT/EP2017/051203
International Filing Date 20.01.2017
IPC
C07D 207/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04having no double bonds between ring members or between ring members and non-ring members
06with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
A61K 31/65 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
65Tetracyclines
CPC
A61K 31/65
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
65Tetracyclines
A61K 9/0053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
A61K 9/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
Applicants
  • SANDOZ AG [CH]/[CH]
Inventors
  • LENGAUER, Hannes
Agents
  • PRÜFER & PARTNER MBB
Priority Data
EP16152468.122.01.2016EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CRYSTALLINE ERAVACYCLINE BIS-HYDROCHLORIDE
(FR) BIS-CHLORHYDRATE D'ÉRAVACYCLINE CRISTALLINE
Abstract
(EN) The invention relates to crystalline eravacycline bis-hydrochloride and to a process for its preparation. Furthermore, the invention relates to the use of crystalline eravacycline bis-hydrochloride for the preparation of pharmaceutical compositions. The invention further relates to pharmaceutical compositions comprising an effective amount of crystalline eravacycline bis-hydrochloride. The pharmaceutical compositions of the present invention can be used as medicaments, in particular for treatment and/ or prevention of bacterial infections e.g. caused by Gram negative pathogens or Gram positive pathogens, in particular caused by multidrug resistant Gram negative pathogens. The pharmaceutical compositions of the present invention can thus be used as medicaments for e.g. the treatment of complicated intra-abdominal and urinary tract infection
(FR) La présente invention concerne du bis-chlorhydrate d'éravacycline cristallin et son procédé de préparation. En outre, l'invention concerne l'utilisation du bis-chlorhydrate d'éravacycline cristallin dans la préparation de compositions pharmaceutiques. L'invention concerne également des compositions pharmaceutiques comprenant une quantité efficace de bis-chlorhydrate d'éravacycline cristallin. Les composition pharmaceutiques de la présente invention peuvent être utilisées comme médicaments, en particulier pour le traitement et/ou la prévention des infections bactériennes telles que celles causées par les pathogènes à Gram négatif ou positif, en particulier par les pathogènes à Gram négatif multirésistants. Les compositions pharmaceutiques de la présente invention peuvent ainsi être utilisées comme médicaments destinés par exemple au traitement des infections intra-abdominales et urinaires compliquées.
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