WO2017115780 OINTMENT

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Publication Number WO/2017/115780

Publication Date 06.07.2017

International Application No. PCT/JP2016/088843

International Filing Date 27.12.2016

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CPC

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Applicants

OTSUKA PHARMACEUTICAL CO., LTD. [JP]/[JP]

Inventors

MURAKAMI, Yoshihiro
MATSUSHITA, Hitoshi
MATSUMOTO, Kengo
OKADA, Minoru
YUKI, Yohei
KOYAMA, Noriyuki
KANAI, Naohiko

Agents

SAEGUSA & PARTNERS

Priority Data

2015-256784

28.12.2015

Publication Language English (en)

Filing Language English (EN)

Designated States

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Title

(EN) OINTMENT

(FR) POMMADE

Abstract

(EN) An ointment is provided. The ointment stably comprises an oxazole compound that has specific inhibitory activity against PDE4 and that is represented by the following formula (11). The ointment can be efficiently absorbed into the skin.

(FR) La présente invention concerne une pommade. Cette pommade comprend de manière stable un composé oxazole qui présente une activité inhibitrice spécifique contre PDE4 et qui est représenté par la formule (11). Cette pommade peut être absorbée efficacement par la peau.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
263	Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02	not condensed with other rings
30	having two or three double bonds between ring members or between ring members and non-ring members
32	with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42	Oxazoles
421	1,3-Oxazoles, e.g. pemoline, trimethadione

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17	Drugs for dermatological disorders

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
263	Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02	not condensed with other rings
30	having two or three double bonds between ring members or between ring members and non-ring members
32	with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42	Oxazoles
421	1,3-Oxazoles, e.g. pemoline, trimethadione

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1. WO2017115780 - OINTMENT

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44	Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44	Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin