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1. (WO2017114851) METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A MICROSATELLITE UNSTABLE CANCER

Pub. No.:    WO/2017/114851    International Application No.:    PCT/EP2016/082745
Publication Date: Fri Jul 07 01:59:59 CEST 2017 International Filing Date: Thu Dec 29 00:59:59 CET 2016
IPC: G01N 33/574
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
ASSISTANCE PUBLIQUE – HÔPITAUX DE PARIS
LIGUE NATIONALE CONTRE LE CANCER
SORBONNE UNIVERSITE
Inventors: DUVAL, Alex
ANDRE, Thierry
SVRCEK, Magali
DE REYNIES, Aurélien
MARISA, Laetitia
Title: METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A MICROSATELLITE UNSTABLE CANCER
Abstract:
The present invention relates to methods for predicting the survival time of patients suffering from a micro satellite unstable cancer. In particular, the present invention relates to a method for predicting the survival time of a patient suffering from a micro satellite unstable cancer comprising i) determining the expression level of at least one gene encoding for an immune checkpoint protein in a tumor tissue sample obtained from the patient, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value or concluding that the patient will have a short survival time when the level determined at step i) is higher than the predetermined reference value.