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1. WO2017114851 - METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A MICROSATELLITE UNSTABLE CANCER

Publication Number WO/2017/114851
Publication Date 06.07.2017
International Application No. PCT/EP2016/082745
International Filing Date 28.12.2016
IPC
G01N 33/574 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
CPC
G01N 2333/90241
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
90Enzymes; Proenzymes
902Oxidoreductases (1.)
90241acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
G01N 2800/52
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
52Predicting or monitoring the response to treatment; Prognosis
G01N 2800/56
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
56Staging of a disease; Further complications associated with the disease
G01N 33/57419
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
574for cancer
57407Specifically defined cancers
57419of colon
Applicants
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • ASSISTANCE PUBLIQUE – HÔPITAUX DE PARIS [FR]/[FR]
  • LIGUE NATIONALE CONTRE LE CANCER [FR]/[FR]
  • SORBONNE UNIVERSITE [FR]/[FR]
Inventors
  • DUVAL, Alex
  • ANDRE, Thierry
  • SVRCEK, Magali
  • DE REYNIES, Aurélien
  • MARISA, Laetitia
Agents
  • COLLIN, Matthieu
Priority Data
15307157.629.12.2015EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A MICROSATELLITE UNSTABLE CANCER
(FR) MÉTHODES PERMETTANT DE PRÉDIRE LE TEMPS DE SURVIE DE PATIENTS SOUFFRANT D'UN CANCER INSTABLE MICROSATELLITAIRE
Abstract
(EN)
The present invention relates to methods for predicting the survival time of patients suffering from a micro satellite unstable cancer. In particular, the present invention relates to a method for predicting the survival time of a patient suffering from a micro satellite unstable cancer comprising i) determining the expression level of at least one gene encoding for an immune checkpoint protein in a tumor tissue sample obtained from the patient, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value or concluding that the patient will have a short survival time when the level determined at step i) is higher than the predetermined reference value.
(FR)
La présente invention concerne des méthodes permettant de prédire le temps de survie de patients souffrant d'un cancer instable microsatellitaire. En particulier, la présente invention concerne un procédé permettant de prédire le temps de survie d'un patient souffrant d'un cancer instable microsatellitaire consistant à i) déterminer le niveau d'expression d'au moins un gène codant pour une protéine de point de contrôle immunitaire dans un échantillon de tissu tumoral obtenu auprès d'un patient, ii) comparer le niveau d'expression déterminé à l'étape i) avec une valeur de référence prédéterminée et iii) conclure que le sujet aura un court temps de survie lorsque le niveau déterminé à l'étape i) est inférieur à la valeur de référence prédéterminée ou conclure que le sujet aura un court temps de survie lorsque le niveau déterminé à l'étape i) est supérieur à la valeur de référence prédéterminée.
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Latest bibliographic data on file with the International Bureau