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1. (WO2017112899) COVALENT POLYMER-ANTIGEN CONJUGATED PARTICLES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/112899 International Application No.: PCT/US2016/068423
Publication Date: 29.06.2017 International Filing Date: 22.12.2016
IPC:
A61K 39/385 (2006.01) ,A61K 47/00 (2006.01) ,A61K 9/127 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
Applicants:
COUR PHARMACEUTICALS DEVELOPMENT COMPANY INC. [US/US]; 2215 Sanders Road, Suite 425 Northbrook, Illinois 60062, US
Inventors:
PEARSON, Ryan; US
GETTS, Daniel R.; US
PUISIS, John; US
HERRMANN, James; US
Agent:
NEVILLE, Katherine, L.; US
FULLER, Alyson C.; US
VEITENHEIMER, Erich M.; US
CHRISTIANSEN, William T.; US
LAHERTY, Carol; US
ROGEL, Mark E.; US
MASHRUWALA, Mary Anne; US
NUDELMAN, Aaron S.; US
NGUYEN, Thu; US
HUNDLEY, Jeffrey E.; US
TEAGUE, Lawrence J.; US
Priority Data:
62/292,09805.02.2016US
62/387,18323.12.2015US
Title (EN) COVALENT POLYMER-ANTIGEN CONJUGATED PARTICLES
(FR) PARTICULES CONJUGUÉES PAR COVALENCE DE TYPE POLYMÈRE-ANTIGÈNE
Abstract:
(EN) The present invention provides compositions comprising tolerizing immune modified particles (TIMPs) and methods for using and making said TIMPs. In particular, carrier polymer is covalently conjugated with antigenic peptide before particle formation, which allows for exquisite control of particle size and antigen encapsulation (e.g., for use in eliciting induction of immunological tolerance).
(FR) La présente invention concerne des compositions comprenant des particules modifiées induisant une tolérance immunitaire (TIMP) et des procédés d'utilisation et de production desdites TIMP. En particulier, un polymère de support est conjugué par covalence à un peptide antigénique avant formation des particules, pour permettre un extrême contrôle de la granulométrie et l'encapsulation de l'antigène (p. ex., pour pouvoir provoquer l'induction d'une tolérance immunologique).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016379413CA3008892IL260074KR1020180101410EP3393514