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1. (WO2017112824) METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/112824 International Application No.: PCT/US2016/068138
Publication Date: 29.06.2017 International Filing Date: 21.12.2016
IPC:
C07K 16/28 (2006.01) ,A61K 38/26 (2006.01) ,A61K 39/395 (2006.01) ,A61P 3/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
26
Glucagons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
Applicants:
AMGEN INC. [US/US]; One Amgen Center Drive M/S 28-2-C Thousand Oaks, California 91320-1799, US
Inventors:
YIE, Junming; US
SHI, Donghui; US
LLOYD, David J.; US
WANG, Jinghong; US
SIVITS, JR., Glenn N.; US
VENIANT-ELLISON, Murielle M.; US
KOMOROWSKI, Renee; US
AGRAWAL, Neeraj; US
BATES, Darren L.; US
CLAVETTE, Brandon C. P.; CA
FOLTZ, Ian N.; CA
HO, Shu-yin; US
MURAWSKY, Christopher; CA
MIN, Xiaoshan; US
WANG, Zhulun; US
Agent:
DERMOTT, Jonathan M.; US
Priority Data:
62/337,79917.05.2016US
62/387,48623.12.2015US
62/420,41510.11.2016US
Title (EN) METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING BINDING PROTEINS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) IN COMBINATION WITH GLP-1 AGONISTS
(FR) PROCÉDÉ DE TRAITEMENT OU D'AMÉLIORATION DE TROUBLES MÉTABOLIQUES À L'AIDE DE PROTÉINES DE LIAISON AU RÉCEPTEUR DU PEPTIDE INHIBITEUR GASTRIQUE (GIPR) EN ASSOCIATION AVEC DES AGONISTES DU GLP-1
Abstract:
(EN) Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
(FR) L'invention concerne des méthodes permettant de traiter des maladies et des troubles métaboliques en utilisant une protéine de liaison d'antigène spécifique du polypeptide du récepteur du peptide inhibiteur gastrique (GIPR). Dans divers modes de réalisation, la maladie ou le trouble métabolique est le diabète de type 2, l'obésité, la dyslipidémie, la glycémie élevée, le taux d'insuline élevé et la néphropathie diabétique. Dans certains modes de réalisation, la protéine de liaison d'antigène est administrée en association avec un agoniste du récepteur du GLP-1.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa201806970AU2016378739CA3009650MYPI 2018000984IL259940SG11201805255T
KR1020180108602EP3394104IN201817027078BR112018012833EA201891323CR20180378
ID2019/00383CN109715662