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1. (WO2017112815) CORTISTATIN ANALOGS AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/112815 International Application No.: PCT/US2016/068125
Publication Date: 29.06.2017 International Filing Date: 21.12.2016
IPC:
C07D 519/00 (2006.01) ,C07D 493/08 (2006.01) ,C07K 16/26 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
519
Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
08
Bridged systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
26
against hormones
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US/US]; 17 Quincy St Cambridge, MA 02138, US
Inventors:
SHAIR, Matthew, D.; US
PELISH, Henry, Efrem; US
Agent:
BELLOWS, Brent, R.; US
KNOWLES, Sherry, M.; US
Priority Data:
62/297,49419.02.2016US
62/387,24623.12.2015US
Title (EN) CORTISTATIN ANALOGS AND USES THEREOF
(FR) ANALOGUES DE LA CORTISTATINE ET LEURS UTILISATIONS
Abstract:
(EN) Specific Cortistatin derivatives with advantageous properties for in vivo administration to a host, including a human, in need thereof are provided. These novel species have advantageous pharmacokinetics, low toxicity, low to moderate hERG activity, and/or other pharmacological properties which make them stand out among the class of Cortistatins as superior candidates for human administration.
(FR) L'invention concerne des dérivés spécifiques de la cortistatine présentant des propriétés avantageuses pour l'administration in vivo à un hôte, y compris un humain, qui en a besoin. Ces nouvelles espèces ont des propriétés pharmacocinétiques avantageuses, une faible toxicité, une activité h-erg faible à modérée, et/ou d'autres propriétés pharmacologiques qui les distinguent dans la classe des cortistatines comme meilleurs candidats pour l'administration humaine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2016377678CA3009324MYPI 2018001017IL260123SG11201805092WKR1020180095051
EP3394072CN108699085IN201817027249BR112018012647EA201891511PH1/2018/501351
ID2019/00536