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1. (WO2017112809) SYSTEM AND METHOD FOR SOLUTION PHASE GAP PEPTIDE SYNTHESIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/112809 International Application No.: PCT/US2016/068112
Publication Date: 29.06.2017 International Filing Date: 21.12.2016
IPC:
A61K 38/31 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
31
Somatostatins
Applicants:
TEXAS TECH UNIVERSITY SYSTEM [US/US]; Office of Technology Commercialization Box. 42007 Lubbock, TX 79409-2007, US
Inventors:
LI, Guigen; US
SEIFERT, Cole; US
Agent:
ANDERSON, Kristopher, Lance; US
DICKINSON WRIGHT PLLC; 1825 Eye St. N.w. Suite 900 Washington, DC 20006, US
Priority Data:
62/270,43221.12.2015US
Title (EN) SYSTEM AND METHOD FOR SOLUTION PHASE GAP PEPTIDE SYNTHESIS
(FR) SYSTÈME ET PROCÉDÉ DE SYNTHÈSE DE PEPTIDES GAP EN PHASE SOLUTION
Abstract:
(EN) Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.
(FR) L'invention concerne un système et un procédé de synthèse de peptides en phase solution selon la stratégie Fmoc/tBu comprenant le développement d'un nouveau groupe de protection GAP de type benzyle, et ses utilisations. Ce nouveau groupe de protection GAP est utilisé à la place du support polymère, pour faciliter la synthèse des peptides selon la stratégie Fmoc de C à N sans chromatographie, recristallisation ou supports polymères. Le groupe GAP peut être ajouté ou supprimé à un rendement élevé.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3009065IL260168KR1020180093072EP3393499IN201817025746CN108697770