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1. (WO2017112802) MINERAL-BASED NANOPARTICLES FOR ARTHRITIS TREATMENT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/112802 International Application No.: PCT/US2016/068099
Publication Date: 29.06.2017 International Filing Date: 21.12.2016
IPC:
A61K 9/51 (2006.01) ,A61K 47/04 (2006.01) ,A61K 49/18 (2006.01) ,B82Y 5/00 (2011.01) ,B82Y 30/00 (2011.01) ,C01B 33/00 (2006.01) ,C08K 3/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
04
Non-metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18
characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
30
Nano-technology for materials or surface science, e.g. nano-composites
C CHEMISTRY; METALLURGY
01
INORGANIC CHEMISTRY
B
NON-METALLIC ELEMENTS; COMPOUNDS THEREOF
33
Silicon; Compounds thereof
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
K
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES AS COMPOUNDING INGREDIENTS
3
Use of inorganic ingredients
34
Silicon-containing compounds
Applicants:
THE TEXAS A&M UNIVERSITY SYSTEM [US/US]; 3369 TAMU College Station, TX 77843-3369, US
Inventors:
GAHARWAR, Akhilesh, K.; US
CARROW, James, K.; US
Agent:
GOPALAKRISHNAN, Lekha; US
MOON, William, Allen; US
UDOVICH, Samuel, A.; US
LOVELL, David, A.; US
GOPALAKRISHANAN, Lekha; US
Priority Data:
62/270,40321.12.2015US
Title (EN) MINERAL-BASED NANOPARTICLES FOR ARTHRITIS TREATMENT
(FR) NANOPARTICULES À BASE DE MINÉRAL POUR LE TRAITEMENT DE L'ARTHRITE
Abstract:
(EN) Aspects of the invention are directed to mineral-based nanoparticles comprising silicate nanoparticles that induce human mesenchymal stem cells (hMSCs) into a cartilage-lineage through the upregulation of cartilage-specific genes resulting in the transformation of the cell phenotype into that of a chondrocyte, i.e., a cartilage producing cell. The silicate nanoparticles are synthesized through a process where the precipitate of sodium silicate is mixed with one or more elements and compounds and milled into nanoparticles.
(FR) Des aspects de l'invention concernent des nanoparticules à base de minéral comprenant des nanoparticules de silicate qui induisent des cellules souches mésenchymateuses humaines (hMSC) dans un lignage de cartilage par régulation à la hausse de gènes spécifiques de cartilage de manière à conduire à la transformation du phénotype cellulaire en celui d'un chondrocyte, c'est-à-dire une cellule produisant du cartilage. Les nanoparticules de silicate sont synthétisées par un procédé dans lequel le précipité de silicate de sodium est mélangé avec un ou plusieurs éléments et composés et broyé en nanoparticules.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20180360768