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1. (WO2017112492) PROTECTING RNAS FROM DEGRADATION USING ENGINEERED VIRAL RNAS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/112492 International Application No.: PCT/US2016/066723
Publication Date: 29.06.2017 International Filing Date: 14.12.2016
IPC:
A61K 48/00 (2006.01) ,C07H 21/02 (2006.01) ,C07H 21/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE [US/US]; 1800 Grant Street, 8th Floor Denver, CO 80203, US
Inventors:
KIEFT, Jeffrey, S.; US
CHAPMAN, Erich, G.; US
COSTANTINO, David, A.; US
HESSELBERTH, Jay, R.; US
MACFADDEN, Andrea; US
AKIYAMA, Benjamin; US
Agent:
HOWERTON, Thomas, C.; US
KELLY, Gilbert, Thomson; US
HAMDAN, Maha, A.; US
CARROLL, Peter; US
Priority Data:
62/270,98622.12.2015US
Title (EN) PROTECTING RNAS FROM DEGRADATION USING ENGINEERED VIRAL RNAS
(FR) PROTECTION D'ARN DE LA DÉGRADATION À L'AIDE D'ARN VIRAUX MODIFIÉS
Abstract:
(EN) This invention is in the field of molecular biology, gene expression, functional genomics, and bioinformatics and relates to novel RNA and related structures and methods of use thereof that enables modulation of gene expression and preservation of particular transcriptome targets. The invention contemplates various applications of RNA sequences derived from the genomic RNA of flaviviruses (FVs) and the application of such features in combination with heterologous sequences.
(FR) La présente invention concerne le domaine de la biologie moléculaire, l'expression génique, la génomique fonctionnelle et de la bioinformatique et concerne un nouvel ARN et des structures associées ainsi que des méthodes d'utilisation associées qui permettent la modulation de l'expression génique et la conservation de cibles de transcriptome particulières. L'invention concerne également diverses applications de séquences d'ARN dérivées de l'ARN génomique des flavivirus (FV) et l'application de ces caractéristiques en combinaison avec des séquences hétérologues.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3393524