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1. (WO2017111601) COMPOSITION AND METHOD FOR TREATING INFECTIONS CAUSED BY VANCOMYCIN-RESISTANT INFECTIOUS AGENTS IN A SUBJECT
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/111601 International Application No.: PCT/NL2016/050919
Publication Date: 29.06.2017 International Filing Date: 23.12.2016
IPC:
A61K 38/14 (2006.01) ,A61K 31/198 (2006.01) ,A61P 31/04 (2006.01) ,C12Q 1/37 (2006.01) ,G01N 33/569 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
14
Peptides containing saccharide radicals; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
37
involving peptidase or proteinase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
UNIVERSITEIT LEIDEN [NL/NL]; Rapenburg 70 2311 EZ Leiden, NL
Inventors:
VAN DER AART, Lizah Tanja; NL
LEMMENS, Nicole Angélique; NL
VAN WAMEL, Willem Jan Bastiaan; NL
VAN WEZEL, Gilles Philippus; NL
Agent:
JANSEN, C.M.; NL
Priority Data:
15202760.324.12.2015EP
Title (EN) COMPOSITION AND METHOD FOR TREATING INFECTIONS CAUSED BY VANCOMYCIN-RESISTANT INFECTIOUS AGENTS IN A SUBJECT
(FR) COMPOSITION ET MÉTHODE DESTINÉES À TRAITER DES INFECTIONS PROVOQUÉES PAR DES AGENTS INFECTIEUX RÉSISTANT À LA VANCOMYCINE CHEZ UN SUJET
Abstract:
(EN) The invention is related to vancomycin resistance and in particular to compositions comprising vancomycin for use in inhibiting growth of a vancomycin-resistant microorganism or for use in treating a subject infected with a vancomycin-resistant pathogen. In one aspect the invention provides a composition comprising vancomycin and d-alanine. The invention also provides means and methods for treating a subject infected with a vancomycin resistant microorganism. The invention further provides bacteria with a functionally deactivated gene in the vancomycin resistance cluster.
(FR) L'invention concerne la résistance à la vancomycine et en particulier des compositions comprenant de la vancomycine destinées à être utilisées pour inhiber la croissance d'un micro-organisme résistant à la vancomycine ou pour traiter un sujet infecté par un agent pathogène résistant à la vancomycine. Selon un aspect, l'invention concerne une composition comprenant de la vancomycine et une d-alanine, ainsi que des moyens et des méthodes pour traiter un sujet infecté par un micro-organisme résistant à la vancomycine. Des bactéries contenant un gène du groupe des gènes de résistance à la vancomycine fonctionnellement désactivé sont en outre décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3393491US20190000789