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1. (WO2017111569) PHARMACEUTICAL COMBINATION AND FORMULATION FOR THE TREATMENT OF EYE DISEASES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/111569 International Application No.: PCT/MX2015/000223
Publication Date: 29.06.2017 International Filing Date: 21.12.2015
IPC:
A61K 31/47 (2006.01) ,A61K 38/43 (2006.01) ,A61P 27/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43
Enzymes; Proenzymes; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
Applicants:
CLINICA DE AVANCES OCULARES, S.A.P.I. DE C.V. [MX/MX]; Av. Diagonal H Cortes 2990 interior 2 Col. Vallarta Norte Guadalajara, Jalisco, 44690, MX
Inventors:
CHOZA ROMERO, Laura Elena; MX
CHOZA ROMERO, Andres Abelino; MX
CHOZA JAIME, Laura Leticia; MX
Agent:
CHOZA ROMERO, Laura Elena; MX
Priority Data:
Title (EN) PHARMACEUTICAL COMBINATION AND FORMULATION FOR THE TREATMENT OF EYE DISEASES
(ES) COMBINACIÓN Y FORMULACIÓN FARMACÉUTICA, PARA EL TRATAMIENTO DE ENFERMEDADES OCULARES
(FR) COMBINAISON ET FORMULATION PHARMACEUTIQUES POUR LE TRAITEMENT DE MALADIES OCULAIRES
Abstract:
(EN) The invention relates to a pharmaceutical combination based on serratiopeptidase as an anti-inflammatory and analgesic, at least one quinolone as an antimicrobial, and an amino acid as a stabiliser of the serratiopeptidase. The invention also relates to a pharmaceutical formulation for the treatment of eye diseases, comprising said pharmaceutical combination, a thickening agent, an excipient and double-distilled water. The invention further relates to a method for preparing said formulation, comprising: producing a first mixture of serratiopeptidase, at least one quinolone, an amino acid, at least one liposome and double-distilled water, mixing with an agitation of 500-700 rpm; producing a second mixture of the thickener with double-distilled water, mixing with an agitation of 500 rpm for 20 mins; sterilising the mixture with wet steam at 120°C for 15 mins; and cooling same to approximately 30-36°C; and producing a third mixture, comprising the mixing of the excipients of said formulation and mixing the first, second and third mixture.
(ES) Una combinación farmacéutica a base de Serratiopeptidasa como antiinflamatorio y analgésico; al menos, una Quinolona como antimicrobiano; y un aminoácido, como estabilizador de la Serratiopeptidasa. Una formulación farmacéutica para el tratamiento de enfermedades oculares, que comprende la combinación farmacéutica antes descrita; un agente viscosante, un excipiente; y agua bidestilada. Un método para preparar dicha formulación que comprende: obtener una primera mezcla de Serratiopeptidasa, al menos una Quinolona, un Aminoácido, al menos un Liposoma, y agua bidestilada, mezclando con agitación de 500-700 rpm; obtener una segunda mezcla del viscosante con agua bidestilada mezclando con agitación a 500 rpm, 20 min; esterilizar la mezcla con vapor húmedo a 120 °C, 15 min; y enfriar aproximadamente a 30-36 °C; obtener una tercera mezcla, que comprende mezclar los excipientes de dicha formulación y mezclar la primera, segunda y tercera mezcla.
(FR) L'invention concerne une combinaison pharmaceutique à base de serratiopeptidase en tant qu'anti-inflammatoire et analgésique; d'au moins une quinolone en tant qu'antimicrobien; et d'un aminoacide en tant que stabilisateur de la serratiopeptidase. Une formulation pharmaceutique pour le traitement de maladies oculaires comprend la combinaison pharmaceutique décrite précédemment; un agent visqueux, un excipient; et de l'eau bidistillée. Un procédé de préparation de ladite formulation consiste à obtenir un premier mélange de serratiopeptidase, d'au moins une quinolone, d'un aminoacide, d'au moins un liposome, et de l'eau distillée, en mélangeant avec une agitation allant de 500 à 700 rpm; à obtenir un second mélange de l'agent visqueux avec de l'eau bidistillée en mélangeant avec une agitation de 500 rpm, pendant 20 min; à stériliser le mélange avec de la vapeur humide à 120°C pendant 15 min; et à refroidir approximativement à 30-36°C; à obtenir un troisième mélange qui consiste à mélanger les excipients de ladite formulation et à mélanger le premier, le deuxième et le troisième mélange.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)