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1. (WO2017111167) PHARMACEUTICAL PREPARATION CONTAINING LOXOPROFEN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/111167 International Application No.: PCT/JP2016/088739
Publication Date: 29.06.2017 International Filing Date: 26.12.2016
IPC:
A61K 31/192 (2006.01) ,A61K 47/06 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/18 (2017.01) ,A61K 47/22 (2006.01) ,A61K 47/26 (2006.01) ,A61K 47/28 (2006.01) ,A61K 47/38 (2006.01) ,A61K 47/46 (2006.01) ,A61K 9/06 (2006.01) ,A61K 9/08 (2006.01) ,A61K 9/10 (2006.01) ,A61K 9/107 (2006.01) ,A61K 9/12 (2006.01) ,A61P 29/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
16
containing nitrogen
18
Amines; Quaternary ammonium compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
22
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
26
Carbohydrates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
28
Steroids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
38
Cellulose; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
46
Ingredients of undetermined constitution or reaction products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
12
Aerosols; Foams
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
興和株式会社 KOWA COMPANY, LTD. [JP/JP]; 愛知県名古屋市中区錦三丁目6番29号 6-29, Nishiki 3-chome, Naka-ku, Nagoya-shi, Aichi 4608625, JP
Inventors:
薄井 俊樹 USUI, Toshiki; JP
Agent:
特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; 東京都中央区日本橋人形町1丁目3番8号 沢の鶴人形町ビル Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013, JP
Priority Data:
2015-25324125.12.2015JP
2015-25324325.12.2015JP
2015-25324625.12.2015JP
2016-01512529.01.2016JP
2016-01513229.01.2016JP
2016-03560026.02.2016JP
2016-03561326.02.2016JP
2016-08766026.04.2016JP
2016-14305321.07.2016JP
2016-14305921.07.2016JP
2016-14592226.07.2016JP
2016-15990617.08.2016JP
2016-17047101.09.2016JP
Title (EN) PHARMACEUTICAL PREPARATION CONTAINING LOXOPROFEN
(FR) PRÉPARATION PHARMACEUTIQUE CONTENANT DU LOXOPROFÈNE
(JA) ロキソプロフェンを含有する医薬製剤
Abstract:
(EN) Provided is a means of suppressing discoloration of a liquid or semi-solid composition comprising loxoprofen or a salt thereof when stored at high temperature. A pharmaceutical preparation formed by accommodating a liquid or semi-solid composition in a polyolefin resin container, said liquid or semi-solid composition comprising the following components (A) and (B): (A) loxoprofen or a salt thereof; (B) any one of the following components (B-1) to (B-9). (B-1) A terpene; (B-2) a plant or extract from the arnica genus; (B-3) a polyvalent alcohol; (B-4) a cellulose; (B-5) a tocopherol; (B-6) a glycyrrhetinic acid; (B-7) a compound (chlorphenamine, diphenhydramine, etc.) represented by general formula (1) or a salt thereof; (B-8) capsicum annuum or an extract therefrom; (B-9) an organic amine.
(FR) La présente invention concerne un moyen de supprimer la décoloration d'une composition liquide ou semi-solide comprenant du loxoprofène ou un sel de celui-ci lorsqu'elle est stockée à une température élevée. L'invention concerne une préparation pharmaceutique formée en logeant une composition liquide ou semi-solide dans un récipient en résine polyoléfinique, ladite composition liquide ou semi-solide comprenant les constituants (A) et (B) suivants : (A) du loxoprofène ou un sel de celui-ci ; et l'un quelconque des constituants (B-1) à (B-9) suivants. (B-1) Un terpène ; (B-2) une plante ou un extrait du genre arnica ; (B-3) un alcool polyvalent ; (B-4) une cellulose ; (B-5) un tocophérol ; (B-6) un acide glycyrrhétinique ; (B-7) un composé (chlorphénamine, diphénhydramine, etc.) représenté par la formule générale (I) ou un sel de celui-ci ; (B-8) capsicum annuum ou un extrait de celui-ci ; (B-9) une amine organique.
(JA) ロキソプロフェン又はその塩を含有する液状又は半固形状の組成物の、高温保存時における変色を抑制する手段の提供。次の成分(A)及び(B):(A)ロキソプロフェン又はその塩;(B)次の成分(B-1)~(B-9)のいずれか;(B-1)テルペン類(B-2)ウサギギク属の植物又はその抽出物(B-3)多価アルコール(B-4)セルロース類(B-5)トコフェロール類(B-6)グリチルレチン酸類(B-7)一般式(1)で表される化合物(クロルフェニラミン、ジフェン ヒドラミン等)又はその塩(B-8)トウガラシ又はその抽出物(B-9)有機アミンを含有する液状又は半固形状の組成物が、ポリオレフィン系樹脂製容器に収容されてなる、医薬製剤。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020180098233