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1. (WO2017110965) VASOPRESSIN-LIKE ACTION ENHANCER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/110965 International Application No.: PCT/JP2016/088283
Publication Date: 29.06.2017 International Filing Date: 22.12.2016
IPC:
A61K 31/4174 (2006.01) ,A61K 38/00 (2006.01) ,A61K 38/11 (2006.01) ,A61K 45/00 (2006.01) ,A61P 13/02 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
4174
Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10
Peptides having 12 to 20 amino acids
11
Oxytocins; Vasopressins; Related peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
02
of urine or of the urinary tract, e.g. urine acidifiers
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
杏林製薬株式会社 KYORIN PHARMACEUTICAL CO., LTD. [JP/JP]; 東京都千代田区神田駿河台四丁目6番地 6, Kanda Surugadai 4-chome, Chiyoda-ku, Tokyo 1018311, JP
Inventors:
山崎 貴信 YAMAZAKI, Takanobu; JP
Agent:
水野 勝文 MIZUNO, Katsufumi; JP
井出 真 IDE, Makoto; JP
須澤 洋 SUZAWA, Hiroshi; JP
久松 洋輔 HISAMATSU, Yosuke; JP
Priority Data:
2015-25301825.12.2015JP
Title (EN) VASOPRESSIN-LIKE ACTION ENHANCER
(FR) AMPLIFICATEUR DE L'ACTION DE COMPOSÉS DE TYPE VASOPRESSINE
(JA) バソプレシン様作用増強剤
Abstract:
(EN) The present invention addresses the problem of providing a means for ameliorating pollakisuria and nocturia, in particular nocturia caused by polyuria at night by finding a composition that enhances the antidiuretic action of vasopressin or a vasopressin V2 receptor agonist. As the results of studies, it was found that imidafenacin is capable of enhancing the antidiuretic action of vasopressin or a vasopressin V2 receptor agonist. The present invention is completed on the basis of this finding. According to the present invention, the antidiuretic action of vasopressin or a vasopressin V2 receptor agonist can be enhanced by a composition containing imidafenacin so that pollakisuria and nocturia, in particular nocturia caused by polyuria at night can be ameliorated.
(FR) La présente invention aborde le problème consistant à fournir un moyen permettant d'atténuer la pollakiurie et la nycturie, en particulier la nycturie provoquée par la polyurie nocturne en découvrant une composition qui amplifie l'action antidiurétique de la vasopressine ou d'un agoniste du récepteur V2 de la vasopressine. Il a été découvert, dans les résultats des études, que l'imidafénacine permet d'amplifier l'action antidiurétique de la vasopressine ou d'un agoniste du récepteur V2 de la vasopressine. La présente invention est accomplie sur la base de cette découverte. Selon la présente invention, l'action antidiurétique de la vasopressine ou d'un agoniste du récepteur V2 de la vasopressine peut être amplifiée par une composition contenant de l'imidafénacine de sorte à pouvoir atténuer la pollakiurie et la nycturie, en particulier la nycturie provoquée par la polyurie nocturne.
(JA) 【課題】バソプレシンやバソプレシンV2受容体アゴニストの抗利尿作用を増強する組成物を見出すことにより、頻尿や夜間頻尿の改善、特に夜間多尿に起因する夜間頻尿を改善する手段を提供することが、本発明が解決しようとする課題である。検討の結果、イミダフェナシンがバソプレシンやバソプレシンV2受容体アゴニストの抗利尿作用を増強させることを見出し、本発明を完成した。本発明によれば、イミダフェナシンを含有する組成物によりバソプレシン又はバソプレシンV2受容体アゴニストの抗利尿作用を増強させることが可能となり、頻尿や夜間頻尿の改善、特に夜間多尿に起因する夜間頻尿を改善することができる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
KR1020180097551EP3395343US20180344700