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1. (WO2017110881) MEDICINE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/110881 International Application No.: PCT/JP2016/088121
Publication Date: 29.06.2017 International Filing Date: 21.12.2016
IPC:
A61K 31/519 (2006.01) ,A61P 9/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
04
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Applicants:
武田薬品工業株式会社 TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 大阪府大阪市中央区道修町四丁目1番1号 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5408645, JP
Inventors:
松田 貴久 MATSUDA Takahisa; JP
元屋地 孝士 MOTOYAJI Takashi; JP
北村 周治 KITAMURA Shuji; JP
吉田 雅都 YOSHIDA Masato; JP
Agent:
大野 聖二 OHNO, Seiji; JP
松任谷 優子 MATSUTOYA, Yuko; JP
梅田 慎介 UMEDA, Shinsuke; JP
森田 裕 MORITA, Yutaka; JP
Priority Data:
2015-25380925.12.2015JP
Title (EN) MEDICINE
(FR) MÉDICAMENT
(JA) 医薬
Abstract:
(EN) The invention provides a medicine for the prevention or treatment of heart failure. More specifically, the invention provides a medicine for the prevention or treatment of heart failure containing a compound selected from the group consisting of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)-N-[1-ethyl-1-(4-methoxyphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-5-(2-fluorophenyl)-2,7,7,7-trimethyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, and salts thereof.
(FR) L'invention concerne un médicament pour la prévention ou le traitement de l'insuffisance cardiaque. Plus spécifiquement, l'invention concerne un médicament pour la prévention ou le traitement de l'insuffisance cardiaque contenant un composé sélectionné au sein du groupe constitué par le (5R)-N-[1-éthyl-1-(4-éthylphényl)propyl]-2,7,7-triméthyl-5-phényl-4,5,6,7-tétrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, le (5R)-N-[1-éthyl-1-(4-méthoxyphenyl)propyl]-2,7,7-triméthyl-5-phenyl-4,5,6,7-tétrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, le (5R)-N-[1-éthyl-1-(4-éthylphényl)propyl]-5-(2-fluorophényl)-2,7,7,7-triméthyl-4,5,6,7-tétrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, et des sels de ces derniers.
(JA) 本発明は、心不全を予防または治療するための医薬を提供する。より具体的には、本発明は、心不全の予防または治療するための、(5R)-N-[1-エチル-1-(4-エチルフェニル)プロピル]-2,7,7-トリメチル-5-フェニル-4,5,6,7-テトラヒドロピラゾロ[1,5-a]ピリミジン-3-カルボキサミド、(5R)-N-[1-エチル-1-(4-メトキシフェニル)プロピル]-2,7,7-トリメチル-5-フェニル-4,5,6,7-テトラヒドロピラゾロ[1,5-a]ピリミジン-3-カルボキサミド、(5R)-N-[1-エチル-1-(4-エチルフェニル)プロピル]-5-(2-フルオロフェニル)-2,7,7-トリメチル-4,5,6,7-テトラヒドロピラゾロ[1,5-a]ピリミジン-3-カルボキサミド、およびそれらの塩からなる群から選ばれる化合物を含有してなる、医薬を提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
CA3009609CN108601784EP3395344